Active ingredientHydralazineCat. No. P-H037-001CAS 86-54-4
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Pharmacopoeial impurity · Hydralazine family
Pharmaceutical analytical standard4-Hydrazinyl-1-Phthalazinamine
Synonyms: 4-hydrazinylphthalazin-1-amine, Dihydralazine Impurity, Dihydralazine Impurity 1
- Cat. No.
- P-H037-009
- CAS
- 649765-80-0
- Alternative CAS
- N/A
- Formula
- C8H9N5
- Molecular weight
- 175.19 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Hydralazine
A vasodilator that relaxes the arteries directly, approved in the United States in 1953 and one of the first blood pressure medicines that could be taken by mouth. It is used in hypertension, including in pregnancy, and in heart failure together with isosorbide dinitrate.
Did you know?It was discovered by chance: the chemists who synthesised it in the mid-1940s were looking for a new antimalarial drug, and during that work they noticed instead that it lowered blood pressure.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Hydralazine family
Active ingredientHydralazineCat. No. P-H037-001CAS 86-54-4
Active ingredientHydralazine HydrochlorideCat. No. P-H037-002CAS 304-20-1
Isotopically labelledHydralazine-d4 HClCat. No. P-H037-003CAS 2749234-32-8
NitrosamineN-Nitroso HydralazineCat. No. P-H037-004
ImpurityDi(phthalazin-1-yl)amineCat. No. P-H037-005CAS 103429-70-5
Impurity1,1-di(phthalazin-1-yl)hydrazineCat. No. P-H037-006CAS 103429-71-6
ImpurityHydralazine Impurity 1Cat. No. P-H037-008CAS 20062-41-3
Impurity7-Chloro-Hydralazine HClCat. No. P-H037-010CAS 6145-58-0Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.