Active ingredientThalidomideCat. No. P-T081-001CAS 50-35-1
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Impurity or related compound · Thalidomide family
Pharmaceutical analytical standard5-Hydroxy Thalidomide
Synonyms: 5-Hydroxythalidomide, 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindole-1,3-dione, Thalidomide-5-OH, alpha-N-(4-Hydroxyphthalimido)-glutarimide, Phthalimide, n-(2,6-dioxo-3-piperidyl)-4-hydroxy-
- Cat. No.
- P-T081-007
- CAS
- 64567-60-8
- Alternative CAS
- 250384-12-4 (alternative CAS, same compound)
- Formula
- C13H10N2O5
- Molecular weight
- 274.23 g/mol
- Category
- Impurity or related compound
Family: Thalidomide
An immunomodulator synthesised in the 1950s that acts on the protein cereblon; in the United States it has been approved since 1998 for erythema nodosum leprosum, a painful complication of leprosy, and since 2006 for multiple myeloma.
Did you know?In 1964 the physician Jacob Sheskin, in Jerusalem, tried it on a critically ill leprosy patient: after sleeping for hours the man could get out of bed unaided, and that chance discovery led to clinical trials in leprosy.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Thalidomide family
Active ingredientThalidomideCat. No. P-T081-001CAS 50-35-1
Isotopically labelledThalidomide-d4Cat. No. P-T081-002CAS 1219177-18-0
Impurity(R)-ThalidomideCat. No. P-T081-003CAS 2614-06-4
ImpurityThalidomide Impurity 1Cat. No. P-T081-004CAS 26581-81-7
ImpurityThalidomide Impurity 2Cat. No. P-T081-005CAS 1479889-22-9
Impurity4-Hydroxy ThalidomideCat. No. P-T081-006CAS 5054-59-1
Impuritycis-5'-Hydroxy ThalidomideCat. No. P-T081-008CAS 203450-07-1
ImpurityN-Hydroxy ThalidomideCat. No. P-T081-009CAS 126663-38-5Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.