Active ingredientAbacavirCat. No. P-A001-001CAS 136470-78-5
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Impurity or related compound · Abacavir family
Pharmaceutical analytical standardAbacavir Carboxylate
Synonyms: Abacavir 5'-carboxylic acid, Abacavir 5'-carboxylate, Abacavir carboxylic acid
- Cat. No.
- P-A001-023
- CAS
- 384380-52-3
- Alternative CAS
- N/A
- Formula
- C14H16N6O2
- Molecular weight
- 300.32 g/mol
- Category
- Impurity or related compound
Family: Abacavir
An antiretroviral against HIV, a carbocyclic guanosine analogue that inhibits the virus's reverse transcriptase: developed in the 1980s by Robert Vince and Susan Daluge, it was approved in the United States in December 1998.
Did you know?It is a classic example of pharmacogenetics: before treatment, DNA is checked for the HLA-B*5701 variant, linked to a hypersensitivity reaction, as confirmed in 2008 by the PREDICT-1 study.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Abacavir family
Active ingredientAbacavirCat. No. P-A001-001CAS 136470-78-5
Active ingredientAbacavir SulfateCat. No. P-A001-002CAS 188062-50-2
Pharmacopoeial impurityAbacavir EP Impurity ACat. No. P-A001-003CAS 136470-79-6
Pharmacopoeial impurityAbacavir EP Impurity BCat. No. P-A001-004CAS 1443421-69-9
Pharmacopoeial impurityAbacavir EP Impurity CCat. No. P-A001-005CAS 124752-25-6
Pharmacopoeial impurityAbacavir EP Impurity DCat. No. P-A001-006CAS 1443421-67-7
Pharmacopoeial impurityAbacavir EP Impurity ECat. No. P-A001-007CAS 208762-35-0
Pharmacopoeial impurityAbacavir EP Impurity FCat. No. P-A001-008CAS 1443421-68-8Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.