Pharmacopoeial impurityAciclovir EP Impurity JCat. No. P-A028-002CAS 166762-90-9
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Active ingredient · Aciclovir family
Pharmaceutical analytical standardAcyclovir
Synonyms: 2-amino-9-(2-hydroxyethoxymethyl)-1H-purin-6-one, Acycloguanosine, Vipral, Virorax, Aciclovirum, Sitavig, Acicloftal, Cargosil, Gerpevir, Novirus, Cyclovir, NSC 758477, NSC 645011, Avaclyr, Aciclovirum (Latin), Aclovir, Clearsore, Duvimex, Lipsore, Ranovir, Soothelip, Soraway, Viralief, Virasorb, Lypsyl, Avert, ViraxPuren, Cymex ultra, Aci Sanorania, Aciclovir von ct, Solutab, Acipen, Acyclo V, Alonga, Aciclovir, Aciclovir Sanorania, Virovir 200, Virovir 400, Virovir 800, Zovirax, Zovir, Maynar, Zyclir, Acyclovir-sidechain-2-3h, Acyclovir (Aciclovir), Aciclovier, Activir, Hascovir, Viropump, AcycloFoam, Avirax, Genvir, Acyclovir Lauriad, ACV & Pluronic F-68, B-LF& ACV, Acyclovir & Pluronic F-68, Poviral, Sitavir, Acic, Aciclovir (JP18/INN), Aciclovir (bw 248u), Acyclovir, Valaciclovir Impurity, Pharmakon1600-01503603, Aciclovir for peak identification 2, NSC 780378
- Cat. No.
- P-A028-024
- CAS
- 59277-89-3
- Alternative CAS
- 69657-51-8 (sodium salt)
- 1628039-62-2 (hydrochloride)
- 261506-45-0 (sodium salt hydrate)
- Formula
- C8H11N5O3
- Molecular weight
- 225.21 g/mol
- Category
- Active ingredient (API)
Family: Aciclovir
A guanosine-analogue antiviral that blocks DNA replication of herpes viruses. Described in 1977 by Gertrude Elion and co-workers and approved in the United States in 1982, it is used against herpes simplex, chickenpox and shingles.
Did you know?It is activated almost only inside infected cells, because the first step is carried out by a viral enzyme. Gertrude Elion was awarded the 1988 Nobel Prize in Medicine together with George Hitchings.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- AciclovirBP 438
- Aciclovir CRSEP A0220000
- Aciclovir for impurity G identification CRSEP Y0002244
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Pharmacopoeial impurityAciclovir EP Impurity RCat. No. P-A028-005
Pharmacopoeial impurityAcyclovir EP Impurity ACat. No. P-A028-006CAS 102728-64-3
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Pharmacopoeial impurityAcyclovir EP Impurity GCat. No. P-A028-009CAS 75128-73-3Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.