Active ingredientAprepitantCat. No. P-A176-001CAS 170729-80-3
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Impurity or related compound · Aprepitant family
Pharmaceutical analytical standardAprepitant Impurity 22
Synonyms: Methyl 2-amino-3-(1H-indol-2-yl)propanoate
- Cat. No.
- P-A176-059
- CAS
- 1379883-12-1
- Alternative CAS
- N/A
- Formula
- C12H14N2O2
- Molecular weight
- 218.26 g/mol
- Category
- Impurity or related compound
Family: Aprepitant
An NK1 receptor antagonist that stops substance P from acting on the nerve centres that trigger vomiting. Approved in 2003 in Europe and the United States, it is used to prevent chemotherapy-induced nausea and vomiting.
Did you know?It was also studied as a possible antidepressant: that project was dropped in 2003, a few months after the molecule had been approved as a medicine against vomiting.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Aprepitant family
Active ingredientAprepitantCat. No. P-A176-001CAS 170729-80-3
Pharmacopoeial impurityAprepitant EP Impurity ACat. No. P-A176-002CAS 170729-76-7
Pharmacopoeial impurityAprepitant EP Impurity BCat. No. P-A176-003CAS 2348441-62-1
Pharmacopoeial impurityAprepitant EP Impurity CCat. No. P-A176-004CAS 2348441-63-2
MetaboliteAprepitant Metabolite 1Cat. No. P-A176-006
MetaboliteAprepitant Metabolite 2 HydrochlorideCat. No. P-A176-007CAS 1333995-14-4
MetaboliteAprepitant Metabolite 3Cat. No. P-A176-008CAS 380499-06-9
MetaboliteAprepitant-M3 MetaboliteCat. No. P-A176-009CAS 419574-04-2Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.