Pharmacopoeial impurityIvermectin EP Impurity BCat. No. P-I108-003CAS 65195-56-4
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Pharmacopoeial impurity · Ivermectin family
Pharmaceutical analytical standardAvermectin B1a
Synonyms: Ivermectin EP Impurity A, Abamectin B1a, Abamectin B1a, Abamectin component B1a, Avermectin A1a, 5-O-demethyl-, Antibiotic C 076B1a, Caswell No. 063AB, Abamectin komponente B1a, Antibiotic C 076A1a, 5-O-demethyl-, Avermectin A(sub 1a), 5-O-demethyl-, Avermectin B1a 100 microg/mL in Acetonitrile, Abamectin B1a 1000 microg/mL in Acetonitrile
- Cat. No.
- P-I108-002
- CAS
- 65195-55-3
- Alternative CAS
- N/A
- Formula
- C48H72O14
- Molecular weight
- 873.09 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Ivermectin
An antiparasitic derived from the avermectins, produced by the soil bacterium Streptomyces avermitilis: introduced in veterinary medicine in the early 1980s, in humans it is used against onchocerciasis (river blindness), filariasis, strongyloidiasis and scabies.
Did you know?The bacterium it comes from was isolated by Satoshi Ōmura from a soil sample collected at the edge of a golf course in Kawana, Japan: for this discovery he shared the 2015 Nobel Prize in Medicine with William Campbell.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
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Pharmacopoeial impurityIvermectin EP Impurity I (4S-Isomer)Cat. No. P-I108-010CAS 1135339-49-9Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.