Active ingredientAvibactamCat. No. P-A222-001CAS 1192500-31-4
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Impurity or related compound · Avibactam family
Pharmaceutical analytical standardAvibactam Impurity 47
Synonyms: Ethyl (2S,5S)-7-oxo-6-phenylmethoxy-1,6-diazabicyclo[3.2.1]octane-2-carboxylate
- Cat. No.
- P-A222-059
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C16H20N2O4
- Molecular weight
- 304.35 g/mol
- Category
- Impurity or related compound
Family: Avibactam
A beta-lactamase inhibitor with a non-beta-lactam structure (a diazabicyclooctane), approved in the United States in 2015 together with ceftazidime: it shields the antibiotic from the enzymes that resistant Gram-negative bacteria use to destroy it.
Did you know?It binds the enzyme covalently but reversibly: when it lets go it has not been broken down, so it comes off intact and can block another beta-lactamase.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Avibactam family
Active ingredientAvibactamCat. No. P-A222-001CAS 1192500-31-4
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Isotopically labelledAvibactam-d4 Sodium SaltCat. No. P-A222-004
ImpurityAvibactam Impurity 1Cat. No. P-A222-005CAS 2411591-28-9
ImpurityAvibactam Impurity 2Cat. No. P-A222-006CAS 65275-12-9
ImpurityAvibactam Descarbonyl Impurity Sodium SaltCat. No. P-A222-007CAS 3024782-80-4
ImpurityAvibactam Impurity 4Cat. No. P-A222-010Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.