Pharmacopoeial impurityBufexamac EP Impurity ACat. No. P-B132-002CAS 4547-57-3
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Active ingredient · Bufexamac family
Pharmaceutical analytical standardBufexamac
Synonyms: 2-(4-butoxyphenyl)-N-hydroxyacetamide, Bufexamic acid, Parfenac, Anderm, Paraderm, p-Butoxyphenylacetohydroxamic acid, NSC 758153, p-Butoxyphenylacethydroxamic Acid, Droxaryl, Parfenal, Feximac, Mofenar, Flogicid, Malipuran, Norfemac, Flogocid N plastigel, Benzeneacetamide, 4-butoxy-N-hydroxy-, ACETOHYDROXAMIC ACID, 2-(p-BUTOXYPHENYL)-, Droxarol, Bufessamac, Pharmakon1600-01502003, Para-butoxyphenylacetohydroxamic acid
- Cat. No.
- P-B132-001
- CAS
- 2438-72-4
- Alternative CAS
- N/A
- Formula
- C12H17NO3
- Molecular weight
- 223.27 g/mol
- Category
- Active ingredient (API)
A topical non-steroidal anti-inflammatory drug, used in creams for eczema, sunburn and itching and in suppositories for haemorrhoids; in 2010 the European Medicines Agency recommended its withdrawal because of the risk of allergic contact dermatitis.
Did you know?In 2011 a chemoproteomics study found that it specifically inhibits two epigenetic enzymes, the histone deacetylases HDAC6 and HDAC10: an old skin medicine turned research tool.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Bufexamac CRSEP B1156000
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Pharmacopoeial impurityBufexamac EP Impurity DCat. No. P-B132-005CAS 3413-59-0Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.