Active ingredientCaptoprilCat. No. P-C030-001CAS 62571-86-2
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Pharmacopoeial impurity · Captopril family
Pharmaceutical analytical standardCaptopril EP Impurity D
Synonyms: 3-Bromo-2-methylpropionic acid, 3-bromo-2-methylpropanoic acid, Propanoic acid, 3-bromo-2-methyl-, Propionic acid, 3-bromo-2-methyl-, beta-bromoisobutanoic acid, Captopril impurity d (ep impurity)
- Cat. No.
- P-C030-006
- CAS
- 56970-78-6
- Alternative CAS
- 80586-28-3 (alternative CAS, same compound)
- Formula
- C4H7BrO2
- Molecular weight
- 167.00 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Captopril
The first orally active ACE inhibitor, synthesised in 1975 by Miguel Ondetti, Bernard Rubin and David Cushman and approved in the United States in 1981; it is used for high blood pressure and heart failure.
Did you know?It was born from the venom of the Brazilian pit viper Bothrops jararaca, in which pharmacologist Sérgio Ferreira had discovered peptides that enhance bradykinin and block the ACE enzyme.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Captopril impurity D CRSEP Y0001221
More products in the Captopril family
Active ingredientCaptoprilCat. No. P-C030-001CAS 62571-86-2
Pharmacopoeial impurityCaptopril EP Impurity JCat. No. P-C030-002CAS 64838-55-7
Pharmacopoeial impurityCaptopril EP Impurity ACat. No. P-C030-003CAS 64806-05-9
Pharmacopoeial impurityCaptopril EP Impurity BCat. No. P-C030-004CAS 80629-35-2
Pharmacopoeial impurityCaptopril EP Impurity CCat. No. P-C030-005CAS 26473-47-2
Pharmacopoeial impurityCaptopril EP Impurity ECat. No. P-C030-007CAS 23500-15-4
Pharmacopoeial impurityCaptopril EP Impurity FCat. No. P-C030-008CAS 63250-36-2
Pharmacopoeial impurityCaptopril EP Impurity GCat. No. P-C030-010CAS 76497-39-7Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.