Pharmacopoeial impurityClotrimazole EP Impurity ACat. No. P-C227-002CAS 66774-02-5
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Active ingredient · Clotrimazole family
Pharmaceutical analytical standardClotrimazole
Synonyms: 1-[(2-chlorophenyl)-diphenylmethyl]imidazole, Lotrimin, Canesten, Mycosporin, Mycelex, Empecid, Mykosporin, Gyne lotrimin, Chlotrimazole, Trimysten, Mycelex G, Rimazole, Tibatin, Gynix, Mono-baycuten, Mycelex Troches, Pedisafe, Veltrim, Desamix F, Canifug, Gyne-Lotrimin Combination Pack, Trivagizole, Jidesheng, Diphenyl-(2-chlorophenyl)-1-imidazolylmethane, Klotrimazole, Kanesten, Coltrimazole, Actavall, Alevazol, Candiden, Careone, Fortinia, Fungederm, Fungicure, Lakesia, Masnoderm, Occulus, Pedesil, Privacom, Ringworm, Trimazole, Abtrim, TheraPlus, UpandUp, Antifungal Soap, Canesten af, Canesten vc, Heb Antifungal, Mycelex Troche, Signature Care, Theraplus Plus, Clotrima Top, Fungistat Max, Mycil gold, Cura Hongo, Cura Hongos, Skin Repair, Canesten internal, Athlete s Foot, Fortinia OF, Micotrin AC, Mycozyl AC, Ringworm treatment, Equate Jock Itch, Kroger Jock Itch, Rexall Jock Itch, Target Jock Itch, Dynarex Antifungal, Fungazoil Advanced, Canesten crm combi, Dermatin Antifungal, Fungicure Intensive, Shoprite Antifungal, Hua Tuo Xian Gao, Aspiera Anti-fungal, Aardora Anti-Fungal, Walgreens Jock Itch, Aptrimazole, Fungicure Liquid Gel, Jock Itch Antifungal, Kroger Athletes Foot, Meijer Athletes Foot, Publix Athletic Foot, Rexall Athletes Foot, Pro-EX Anti Fungal, Athlete S Foot Afac, Cura Hongo Antifungal, PerfectHeal Antifungal, Canesten v, Cura Hongos Antifungal, Clotrimazol dual, Jock-eze, WinCo Foods Antifungal, Cvs Antifungal Ringworm, Footlogix intensive care, PRO-EX, Akin anti-fungal, Pedesil Maximum Strength, Terrasil Tinea Treatment, TerrasilMed ANTIFUNGAL, Terrasil Fungal Treatment, Our Family Athletes Foot, Signature Care Jock Itch, Healthy Accents Antifungal, Dr Sheffield Athletes Foot, Terrasil Ringworm Treatment, Forticept Antifungal Cooling, Quality Choice Athletes Foot, Rite Aid Antifungal Ringworm, Terrasil Tinea Treatment Max, Western Family Athletes Foot, Forticept Antifungal Foot Gel, Lucky Supersoft Athletes Foot, Goodsense athletes foot, Fastrin Anti-Fungal Skin Care, Smooth Gator Fungus Eliminator, Terrasil Anti-fungal Treatment, au kah chuen antifungal, Terrasil Ringworm Treatment Max, Terrasil Rapid-clear Anti-fungal, Blossom Pharmaceuticals Antifungal, Terrasil Antifungal Cleansing Bar, Athletes Foot Antifungal Antifungal, Hua tuo xian gao antifungal, Terrasil Anti-fungal Treatment Max, Cvs Pharmacy Itch Relief Antifungal, Aardora Anti-Fungal Maximum Strength, Terrasil SERIOUS TINEA TREATMENT, Terrasil SERIOUS FUNGAL TREATMENT, Fungicure Manicure Pedicure Liquid Gel, RoyceDerm Tea Tree Oil Antifungal Soap., Footlogix Intensive Care Diabetic Formula, Terrasil JockItch Treatment Maximum Strength, Botanimedix TineaRX Antifungal Drying Emulsion, Terrasil Athletes Foot AntiFungal Treatment Max, Dermatin, Mycelex OTC, Canestine, Lotrimin Af, Fem Care, Lotrimax, Mycelax, Mycofug, Bis-phenyl-(2-chlorophenyl)(1-imidazoyl)methane, Methane, bis-phenyl-(2-chlorophenyl)-1-imidazolyl-, Bisphenyl-(2-chlorphenyl)-1-imidazolyl-methan, Clotrimaderm, Canestene, Clomatin, Cutistad, Esparol, Stiemazol, Nalbix, Lotrimin Lotion, Gino-Lotremine, Myclo-Gyne
- Cat. No.
- P-C227-001
- CAS
- 23593-75-1
- Alternative CAS
- 117829-71-7 (alternative CAS, same compound)
- Formula
- C22H17ClN2
- Molecular weight
- 344.84 g/mol
- Category
- Active ingredient (API)
An antifungal of the imidazole family discovered in 1969: it is applied to the skin and mucous membranes against fungal skin infections and vaginal and oral thrush, and it is on the WHO List of Essential Medicines.
Did you know?In the 1990s it was also studied in sickle cell disease: it blocks the Gardos channel of red blood cells, a potassium channel, and reduces their dehydration.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- ClotrimazoleBP 379
- Clotrimazole CRSEP C2430000
- Clotrimazole for peak identification CRSEP Y0000849
More products in the Clotrimazole family
Pharmacopoeial impurityClotrimazole EP Impurity ACat. No. P-C227-002CAS 66774-02-5
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Pharmacopoeial impurityClotrimazole EP Impurity CCat. No. P-C227-004CAS 42074-68-0
Pharmacopoeial impurityClotrimazole EP Impurity ECat. No. P-C227-005CAS 5162-03-8
Pharmacopoeial impurityClotrimazole EP Impurity FCat. No. P-C227-006CAS 15469-97-3
Isotopically labelledClotrimazole-d5Cat. No. P-C227-007CAS 1185076-41-8
NitrosamineN-Nitroso Clotrimazole Impurity 1Cat. No. P-C227-008
ImpurityClotrimazole Impurity 1Cat. No. P-C227-009CAS 717109-43-8Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.