Isotopically labelledCyclopamine-13C3Cat. No. P-C267-002
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Active ingredient · Cyclopamine family
Pharmaceutical analytical standardCyclopamine
Synonyms: Alkaloid V, NSC 734950, Veratraman-3-ol, 17,23-epoxy-, (3beta,23beta)-, Jervine, 11-deoxo-, CYCLOP, Veratraman-3-ol,23-epoxy-, (3-beta,23-beta)-
- Cat. No.
- P-C267-001
- CAS
- 4449-51-8
- Alternative CAS
- 11051-96-0 (alternative CAS, same compound)
- Formula
- C27H41NO2
- Molecular weight
- 411.63 g/mol
- Category
- Active ingredient (API)
A steroidal alkaloid from the corn lily, Veratrum californicum, that blocks the Hedgehog signalling pathway by binding the protein Smoothened: it is a valuable research tool and inspired anticancer drugs such as vismodegib, approved in 2012.
Did you know?Its name comes from the Cyclops: in 1957 Idaho ranchers saw lambs born with a single eye and, after about ten years of investigation, the cause was traced to this plant grazed by the sheep.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Cyclopamine family
Isotopically labelledCyclopamine-13C3Cat. No. P-C267-002
ImpurityCycloposineCat. No. P-C267-003CAS 23185-94-6Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.