Active ingredientCyclophosphamideCat. No. P-C271-001CAS 50-18-0
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Active ingredient · Cyclophosphamide family
Pharmaceutical analytical standardCyclophosphamide Monohydrate
Synonyms: Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate, N,N-Bis(beta-chloroethyl)-N',O-propylenephosphoric acid ester amide monohydrate, N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxaphosphorin-2-amine, 2-oxide monohydrate, N,N-Bis(beta-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate, Cyclic N',O-propylene ester of N,N-bis(2-chloroethyl)phosphorodiamidic acid monohydrate, N,N-Di(2-chloroethyl)amino-N,O-propylene phosphoric acid ester diamide monohydrate, N,N-Bis(2-Chloroethyl)-3,4,5,6-tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate, Endoxan A, Cytoxan, Ciclophosphamide hydrat, Cytoxan hydrate, Neosar, N,N-Bis(beta-cloraethyl) N'-O-propylenphosphorildiamid monohydratum, N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide hydrate, N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide--water (1/1)
- Cat. No.
- P-C271-002
- CAS
- 6055-19-2
- Alternative CAS
- 50-18-0 (anhydrous form)
- Formula
- C7H15Cl2N2O2P·H2O
- Molecular weight
- 279.10 g/mol
- Category
- Active ingredient (API)
Family: Cyclophosphamide
An alkylating agent that damages the DNA of rapidly dividing cells, introduced into clinical use in Germany in 1958. It is used with other medicines against lymphomas, some leukaemias and solid tumours, and also in some autoimmune diseases.
Did you know?Norbert Brock designed it as an inactive 'transport form' that would switch on mainly inside tumours, thanks to enzymes thought to be more abundant there. In fact the liver activates it: the idea was wrong, but the drug worked.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- CyclophosphamideBP 1094
- Cyclophosphamide CRSEP C3250000
More products in the Cyclophosphamide family
Active ingredientCyclophosphamideCat. No. P-C271-001CAS 50-18-0
Pharmacopoeial impurityCyclophosphamide EP Impurity ACat. No. P-C271-003CAS 1797009-12-1
Pharmacopoeial impurityCyclophosphamide EP Impurity DCat. No. P-C271-004CAS 158401-52-6
Pharmacopoeial impurityCyclophosphamide EP Impurity E DihydrochlorideCat. No. P-C271-005CAS 158401-51-5
Pharmacopoeial impurityCyclophosphamide EP Impurity FCat. No. P-C271-006CAS 1071-28-9
Pharmacopoeial impurityCyclophosphamide EP Impurity F HClCat. No. P-C271-007CAS 25457-71-0
Pharmacopoeial impurityCyclophosphamide USP Related Compound A HydrochlorideCat. No. P-C271-008CAS 821-48-7
Isotopically labelled(R,S)-4-Hydroxy Cyclophosphamide-d4 Preparation KitCat. No. P-C271-009CAS 1329838-09-6Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.