Active ingredientDantroleneCat. No. P-D012-001CAS 7261-97-4
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Stable isotope labelled · Dantrolene family
Pharmaceutical analytical standardDantrolene-d4
- Cat. No.
- P-D012-008
- CAS
- 2749234-17-9
- Alternative CAS
- 7261-97-4 (unlabelled form)
- 833480-90-3 (unlabelled form)
- 24868-20-0 (unlabelled form, sodium salt)
- 2421144-31-0 (unlabelled form, sodium salt hydrate)
- 1231953-98-2 (unlabelled form, sodium salt hydrate)
- 14663-23-1 (unlabelled form, sodium salt)
- Formula
- C14H6D4N4O5
- Molecular weight
- 318.28 g/mol
- Category
- Stable isotope labelled
Family: Dantrolene
A muscle relaxant that acts directly on muscle, curbing calcium release through the ryanodine receptor; first described in 1967, it is the main medicine for malignant hyperthermia, a rare reaction to anaesthesia, and is also used for spasticity.
Did you know?Its effect against malignant hyperthermia was shown in the 1970s by South African anaesthetist Gaisford Harrison, in pigs that naturally carry the same genetic predisposition.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Dantrolene family
Active ingredientDantroleneCat. No. P-D012-001CAS 7261-97-4
Active ingredientDantrolene Sodium HydrateCat. No. P-D012-002CAS 24868-20-0
Active ingredientDantrolene Sodium SaltCat. No. P-D012-003CAS 14663-23-1
Pharmacopoeial impurityDantrolene USP Related Compound ACat. No. P-D012-004CAS 301359-05-7
Pharmacopoeial impurityDantrolene USP Related Compound CCat. No. P-D012-005CAS 7147-77-5
Metabolite5-Hydroxy Dantrolene GlucuronideCat. No. P-D012-006
Isotopically labelled5-Hydroxy Dantrolene-d4Cat. No. P-D012-007CAS 1217225-15-4
Impurity(E)-Dantrolene Sodium SaltCat. No. P-D012-009CAS 1231955-65-9Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.