Active ingredientDexrazoxaneCat. No. P-D077-001CAS 24584-09-6
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Impurity or related compound · Dexrazoxane family
Pharmaceutical analytical standardDexrazoxane Impurity 1
Synonyms: 2-[(2-Amino-2-oxoethyl)-[(2S)-1-(3,5-dioxopiperazin-1-yl)propan-2-yl]amino]acetic acid, Dexrazoxane Impurity A, Glycine Metabolite 1, (S)-N-(2-Amino-2-oxoethyl)-N-(1-(3,5-dioxopiperazin-1-yl)propan-2-yl)glycine
- Cat. No.
- P-D077-004
- CAS
- 120418-77-1
- Alternative CAS
- N/A
- Formula
- C11H18N4O5
- Molecular weight
- 286.29 g/mol
- Category
- Impurity or related compound
Family: Dexrazoxane
A cardioprotective agent discovered in 1972: by binding iron it reduces the free radicals through which anthracyclines can damage the heart during chemotherapy. In the US it has also been approved to treat anthracycline extravasation.
Did you know?It is a derivative of EDTA, the famous laboratory chelator: inside cells its molecule is thought to open its ring, taking on the form that can grab iron.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Dexrazoxane family
Active ingredientDexrazoxaneCat. No. P-D077-001CAS 24584-09-6
Impurity2-(2-Amino-2-oxoethoxy)acetamideCat. No. P-D077-002CAS 22064-41-1
Impurity2-HydroxyacetamideCat. No. P-D077-003CAS 598-42-5
ImpurityDexrazoxane Impurity 2Cat. No. P-D077-005
ImpurityDexrazoxane Impurity 3Cat. No. P-D077-006
ImpurityDexrazoxane Impurity 4Cat. No. P-D077-007
ImpurityDexrazoxane Impurity 5Cat. No. P-D077-008
ImpurityDexrazoxane Impurity 6Cat. No. P-D077-009Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.