Pharmacopoeial impurityDimenhydrinate EP Impurity HCat. No. P-D128-002CAS 118-23-0
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Active ingredient · Dimenhydrinate family
Pharmaceutical analytical standardDimenhydrinate
Synonyms: Dramamine, Travelin, Diphenhydrinate, Anautine, Vomex A, Amosyt, Chloranautine, Aviomarin, Dromyl, Gravol, Menhydrinate, Andramine, Diamarin, Dramamin, Dramarin, Permital, Supremal, Teodramin, Xamamina, Antemin, Dramyl, Reise-Engletten, Neo-Navigan, Diphenhydramine Theoclate, Dimenhidrinato, Reidamine, Removine, Emedyl, Faston, Dimenidrinato, Diphenhydramine 8-chlorotheophylline, Diphenhydramine 8-chlorotheophyllinate, N,N-Dimethyl-2-diphenylmethoxyethylamine 8-chlorotheophyllinate, beta-Dimethylaminoethyl benzhydryl ether 1,3-dimethyl-8-chloroxanthine, O-Benzhydryldimethylaminoethanol 8-chlorotheophyllinate, Benzhydryl-beta-dimethylaminoethylether 8-chlorotheophylline, Vertigo Vomex, Motion Aid, Calm X, Theoclate, Diphenhydramine, Driminate, Motion Sickness, Vertigo-vomex s, Airmit Ace, Dramamine Orange, Wal-dram, Dramamine for Kids, Motion Sickness Relief, Dramamine Original Formula, Dramamine, TRAVEL BASIX, Dimenest, Dimentabs, Dramalen, Dramilin, Eldodram, Gravinol, Hydrinate, Novamine, Travelmin, Troversin, Dimate, Theohydramine, Dommanate, Lomarin, Novamin, Gravinol (antiemetic)
- Cat. No.
- P-D128-001
- CAS
- 523-87-5
- Alternative CAS
- N/A
- Formula
- C17H21NO·C7H7ClN4O2
- Molecular weight
- 469.97 g/mol
- Category
- Active ingredient (API)
An antihistamine made of diphenhydramine and 8-chlorotheophylline in a 1:1 ratio, used to prevent and relieve nausea, vomiting and dizziness from motion sickness. It has been in pharmacies since 1949, after studies at Johns Hopkins Hospital in Baltimore.
Did you know?Its effect on motion sickness was discovered by chance in 1947: a patient treated for hives told allergists Leslie Gay and Paul Carliner that her tram rides home were at last free from nausea.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Dimenhydrinate CRSEP D2000000
- Dimenhydrinate for peak identification CRSEP Y0001103
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Pharmacopoeial impurityDimenhydrinate EP Impurity KCat. No. P-D128-008CAS 574-42-5
ImpurityDimenhydrinate Impurity 1Cat. No. P-D128-011CAS 5270-31-5Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
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