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Diphenhydramine Hydrochloride
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Highly Characterized Analytical Standard

Active ingredient · Diphenhydramine family

Pharmaceutical analytical standard

Diphenhydramine Hydrochloride

Synonyms: Allergival, Bendylate, Antitussive, Denydryl, Eldadryl, Fenylhist, Hydramine, Dibenil, Silphen, Beldin, Belix, Diphen, Felben, Bena, Dimedrol hydrochloride, Halbmond, Wehydryl, Resmin, Benzhydramine hydrochloride, Banophen, Difenhydramine hydrochloride, Diphenylhydramine hydrochloride, Benadryl Preservative Free, Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride, Sleepeze, Diphenydramine hydrochloride, beta-Dimethylaminoethyl benzhydryl ether hydrochloride, alpha-Hydroxydiphenylmethane-beta-dimethylaminoethyl ether hydrochloride, Diphenhist, Pharbedryl, Allergies, Aphenap, Benaldryl, Calmatrol, Dicopanol, Dreemon, Equaline, Histaprin, Histergan, Medinex, Naramin, Nightcalm, Sleepia, Somnapure, Somnitabs, Zzzquil, Zzzsleep, Coltex, Fedril, Nytol, Sleep, Tixylix catarrh, Publix allergy, Leader Allergy, Medique Diphen, SleepEze minis, Sohmed Allergy, Allergy DyeFree, Conrx Allergy, Correct Dose, Itch Stopping, Ivy Treatment, Kids Allergy, Qdryl Allergy, Simply Sleep, Tecnu Calagel, Allergy Medicine, Benadryl Allergy, Betr sleep aid, Complete Allergy, Each Relief, Equaline Allergy, Gppe oral soln, Rest Simply, Sleep Tabs, Sleepeze Gelcaps, Sominex Max, Wal-dryl, Leader anti itch, Meijer anti-itch, Wal dryl allergy, Aller-Ben, Geri Dryl, Wal-som, After Bite Xtra, Allergy Childrens, Itch Relief Gel, The Itch Eraser, Welly Calm Balm, Dye-free Allergy, NMNQuil, SleepAid Softgels, Topcare anti itch, AXIM Allergy, AXIV Allergy, Circle K Allergy, Equate Anti Itch, Ez Nite Sleep, Rexall Sleep Aid, Shopko Anti-Itch, Wal-sleep Z, Benadryl Ultratabs, CVS Itch Relief, Dr Kids, Equaline anti-itch, Kids-eeze Allergy, Nighttime Sleepaid, Nitetime sleep aid, Diphenhydraime HCl, IC Ivy Relief, Sleep II, DG Anti-Itch, Dg Health Allergy, M-Dryl, Nytol one-a-night, Sleepeze eze melts, Topcare Zzz Sleep, AXIV-VroZzz, Allergy Get Relief, Benadryl Ultra Tab, Each Relief Equate, Good Sense Allergy, Nightime Sleep Aid, Allergy, Circle K, Only For SLEEP, Atopalm Itch Relief, CuRELIEF, Ez Nite Sleep Aid, Help I Cant Sleep, Instant Itch Relief, Lucky Itch Stopping, On The GO-Dose, Savvy Itch Stopping, Sleep Aid Nighttime, Sleep-Aid Chewables, Allergy Antihistamine, Anti-Itch Wal-Dryl, VICKS NyQuil Kids, Adult Allergy Relief, Allergic Itch Relief, Westlake Itch Relief, AXIV Allergy Relief, CAREALL Anti-Itch, Childrens WAL-DRYL, Nyt Time Sleep Caps, Allergy Relief Caplet, Effective Itch Relief, Kroger Allergy Relief, Meijer Allergy Relief, PhysiciansCare Allergy, CalmCo Allergy Relief, Rite Aid Itch Relief, Dormmy-lon, Family wellness allergy, Good sense itch relief, Itch relif, Sleep-Aid, Circle K, Sunmark Allergy Relief, BONINE Faster-Acting, Good Sense Sleep Time, Gppe cough expect paed, Live Better Anti-Itch, Wal-Sleep Z Nighttime, Allergy Relief Complete, Benadryl Extra Strength, Children Allergy Relief, Complete Allergy Relief, Itch relif cvs, Medique at Home Diphen, Dr Kids Allergy Relief, Dye Free Wal Sleep Z, Equate Itch Relief Gel, Max allergy kids, Premier Value Sleep-aid, Allergy Relief Dye Free, Best Choice Itch Relief, Exchange select sleeptime, Walgreens Stop Itch Gel, Sunmark anti-itch, Geri-dryl Allergy Relief, Allergy Childrens Allergy, Allergy, Lil Drug Store, Anti-Itch Extra Strength, Benadryl Allergy Ultratab, Complete Allergy Medicine, Instant Itch Relief CVS, Select Brand Itch Relief, Siladryl Allergy Medicine, Walgreen Itch Relief Gel, Signature care itch relief, Best Choice Itch Stopping, Childrens Benadryl Allergy, Dermachange Aid Anti-Itch, A Health Itch Relief Gel, Walgreens anti itch, Childrens Allergy Dye Free, Childrens Dye Free Allergy, Dye Free Allergy childrens, Equate Nighttime Sleep Aid, Extra Strength Itch Relief

Cat. No.
P-D141-001
CAS
147-24-0
Alternative CAS
  • 58-73-1 (free base)
  • 110491-04-8 (free base)
  • 114402-66-3 (maleate)
  • 17626-27-6 (hydrobromide)
  • 22048-27-7 (sulfate)
  • 523-87-5 (other salt)
Formula
C17H21NO·HCl
Molecular weight
291.82 g/mol
Category
Active ingredient (API)

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Characterisation level

* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.

Quantity
Talk to a specialist

We reply within 24 hours with a quote and availability. CoA and SDS with every lot.

A first-generation antihistamine synthesised in 1943 at the University of Cincinnati, in George Rieveschl's laboratory; in 1946 it became the first prescription antihistamine approved in the United States. It is used for allergies and itching and, thanks to its sedative effect, as a sleep aid.

Did you know?Rieveschl was looking for a medicine against muscle spasms. Years later, studies of its ability to block serotonin reuptake helped lead to the development of fluoxetine.

The two levels compared

Level 1
Mass balance
Level 2
Mass balance + qNMR
Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR)✓✓
HPLC purity (min. 95%)✓✓
Content by mass balance (min. 90%; peptides: for information only)*✓✓
Content verified by qNMR (small molecules only)·✓
Suitable to qualify it as an in-house primary standard (ICH Q7)·✓

* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.

What you receive

The analytical standard

Shipped under controlled temperature when the molecule requires it.

Certificate of analysis (CoA)

For every lot: identity, purity and assay, with the supporting spectra and chromatograms.

Safety data sheet (SDS)

Sent with every order.

Tracked shipment

Follow your shipment live, from our warehouse to your lab.

Pharmacopoeial standards available

The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.

More products in the Diphenhydramine family

See all 21 products in the family

Frequently asked questions

Is mass balance always performed?

Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.

Can I ask for a different quantity?

Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.

Which level should I choose?

Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.

When will I get the quote?

Within 24 working hours, with price, availability and delivery time.

Need a molecule you cannot find?

Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.