Active ingredientDipivefrine HClCat. No. P-D146-001CAS 64019-93-8
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Pharmacopoeial impurity · Dipivefrine family
Pharmaceutical analytical standardDipivefrine EP Impurity E HCl
- Cat. No.
- P-D146-005
- CAS
- N/A
- Alternative CAS
- 52245-00-8 (free base)
- Formula
- C19H27NO5·HCl
- Molecular weight
- 385.88 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Dipivefrine
An eye drop for open-angle glaucoma that lowers pressure inside the eye: it is a prodrug of adrenaline with two pivalic acid groups, which corneal enzymes remove; described in the mid 1970s.
Did you know?Thanks to its two esters it is about 600 times more lipophilic than adrenaline and crosses the cornea 17 times more readily: a 0.1% eye drop works like a 2% adrenaline one.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Dipivefrine family
Active ingredientDipivefrine HClCat. No. P-D146-001CAS 64019-93-8
Pharmacopoeial impurityDipivefrine EP Impurity C HClCat. No. P-D146-002
Pharmacopoeial impurityDipivefrine EP Impurity C HCl and Dipivefrine EP Impurity D HClCat. No. P-D146-003
Pharmacopoeial impurityDipivefrine EP Impurity FCat. No. P-D146-006
Isotopically labelledDipivefrine-d3Cat. No. P-D146-007
Isotopically labelledDipivefrine-d6 HClCat. No. P-D146-008
Isotopically labelledN-Nitroso Dipivefrine-d3Cat. No. P-D146-009
NitrosamineN-Nitroso DipivefrineCat. No. P-D146-010Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.