Active ingredientDoxofyllineCat. No. P-D183-001CAS 69975-86-6
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Stable isotope labelled · Doxofylline family
Pharmaceutical analytical standardDoxofylline-d4
- Cat. No.
- P-D183-002
- CAS
- 1346599-13-0
- Alternative CAS
- 69975-86-6 (unlabelled form)
- Formula
- C11H10D4N4O4
- Molecular weight
- 270.28 g/mol
- Category
- Stable isotope labelled
Family: Doxofylline
A bronchodilator of the xanthine family, a theophylline derivative carrying a dioxolane ring: synthesised in Italy in the early 1960s and developed as a medicine in the late 1970s, it is used for asthma and chronic obstructive pulmonary disease.
Did you know?Compared with theophylline it has much lower affinity for adenosine receptors, the binding blamed for part of the parent drug's unwanted effects.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Doxofylline family
Active ingredientDoxofyllineCat. No. P-D183-001CAS 69975-86-6
ImpurityDoxofylline Impurity 1Cat. No. P-D183-003CAS 109403-76-1
Impurity7-(2',2'-Diethoxyethyl)theophyllineCat. No. P-D183-004CAS 43135-57-5
ImpurityDoxofylline Impurity 2Cat. No. P-D183-005CAS 1429636-72-5
ImpurityDoxofylline Impurity 3Cat. No. P-D183-006CAS 1021-65-4
ImpurityDoxofylline Impurity 4Cat. No. P-D183-007CAS 1174289-18-9
ImpurityDoxofylline Impurity 5Cat. No. P-D183-008CAS 254760-82-2
ImpurityDoxofylline Impurity 6Cat. No. P-D183-009CAS 1429636-74-7Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.