Active ingredientEncorafenibCat. No. P-E045-001CAS 1269440-17-6
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Impurity or related compound · Encorafenib family
Pharmaceutical analytical standardEncorafenib Impurity 2
Synonyms: 2-Chloro-4-(1-propan-2-ylpyrazol-4-yl)pyrimidine
- Cat. No.
- P-E045-004
- CAS
- 2285221-21-6
- Alternative CAS
- N/A
- Formula
- C10H11ClN4
- Molecular weight
- 222.68 g/mol
- Category
- Impurity or related compound
Family: Encorafenib
An oral anticancer drug that blocks mutated BRAF protein: it is used for melanoma with a BRAF V600 mutation and, since 2020 in the United States, with cetuximab for metastatic colorectal cancer with the BRAF V600E mutation.
Did you know?The code V600E means that in the BRAF protein the amino acid valine at position 600 is replaced by glutamic acid: a single change that keeps the cell's growth signal permanently switched on.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Encorafenib family
Active ingredientEncorafenibCat. No. P-E045-001CAS 1269440-17-6
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ImpurityEncorafenib Impurity 1Cat. No. P-E045-003CAS 1934917-37-9
ImpurityEncorafenib Impurity 3Cat. No. P-E045-005CAS 1269440-58-5
ImpurityEncorafenib Impurity 4Cat. No. P-E045-006CAS 1269440-54-1
ImpurityEncorafenib R-IsomerCat. No. P-E045-007CAS 1269440-29-0![Methyl N-[(2S)-2-aminopropyl]carbamate](https://img.vitasanlabs.com/vsl-struct/P-E045-008.svg?v=41e934f030)
ImpurityMethyl N-[(2S)-2-aminopropyl]carbamateCat. No. P-E045-008CAS 1672679-77-4
ImpurityEncorafenib Impurity 5Cat. No. P-E045-009CAS 2148445-66-1Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.