Active ingredientEverolimusCat. No. P-E143-001CAS 159351-69-6
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Stable isotope labelled · Everolimus family
Pharmaceutical analytical standardEverolimus-d4
Synonyms: Everolimus-(2-hydroxyethyl-D4)
- Cat. No.
- P-E143-007
- CAS
- 1338452-54-2
- Alternative CAS
- N/A
- Formula
- C53H79D4NO14
- Molecular weight
- 962.26 g/mol
- Category
- Stable isotope labelled
Family: Everolimus
An mTOR inhibitor derived from sirolimus (rapamycin): approved in the United States in 2009 for advanced kidney cancer and in 2010 against kidney transplant rejection, it is also used in some breast and neuroendocrine tumours and in coronary stents.
Did you know?The rapamycin it derives from comes from a bacterium found in a soil sample collected on Easter Island (Rapa Nui) during a Canadian expedition in 1964-65: the name honours the island.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Everolimus family
Active ingredientEverolimusCat. No. P-E143-001CAS 159351-69-6
Pharmacopoeial impurityEverolimus EP Impurity BCat. No. P-E143-002CAS 1062122-63-7
Pharmacopoeial impurityEverolimus EP Impurity B Lithium Salt (Mixture of E/Z-Isomers)Cat. No. P-E143-003
Pharmacopoeial impurityEverolimus EP Impurity DCat. No. P-E143-004CAS 2760174-96-5
Pharmacopoeial impurityEverolimus EP Impurity ECat. No. P-E143-005CAS 1237826-25-3
Isotopically labelledEverolimus-13C2-d4Cat. No. P-E143-006CAS 1661009-29-5
ImpurityEverolimus Impurity 1Cat. No. P-E143-008CAS 18928-34-2
ImpurityEverolimus Impurity 2Cat. No. P-E143-009CAS 2607-52-5Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.