Active ingredientFlumatinibCat. No. P-F076-001CAS 895519-90-1
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Impurity or related compound · Flumatinib family
Pharmaceutical analytical standardFlumatinib Impurity
Synonyms: 4-[(4-Methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzoic acid, Flumatinib Mesylate Impurity 1
- Cat. No.
- P-F076-013
- CAS
- 859027-02-4
- Alternative CAS
- 859282-11-4 (free base)
- Formula
- C14H17F3N2O2
- Molecular weight
- 302.30 g/mol
- Category
- Impurity or related compound
Family: Flumatinib
A second-generation BCR-ABL tyrosine kinase inhibitor, approved in China in late 2019 for adults with Philadelphia chromosome-positive chronic myeloid leukaemia in the chronic phase.
Did you know?It is a derivative of imatinib: compared with its parent drug, one of its benzene rings is replaced by a pyridine and a trifluoromethyl group is added, which make additional contacts with the target kinase.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Flumatinib family
Active ingredientFlumatinibCat. No. P-F076-001CAS 895519-90-1
Active ingredientFlumatinib MesylateCat. No. P-F076-002CAS 895519-91-2
Isotopically labelledFlumatinib Impurity 1-d3Cat. No. P-F076-004
Isotopically labelledFlumatinib Mesylate-13C, d3Cat. No. P-F076-005
Isotopically labelledFlumatinib Mesylate-d8Cat. No. P-F076-007
Isotopically labelledFlumatinib-d3Cat. No. P-F076-008
Isotopically labelledN-Desmethyl Flumatinib-d8Cat. No. P-F076-009
NitrosamineN-Nitroso FlumatinibCat. No. P-F076-010Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.