Active ingredient · Glucagon family

Pharmaceutical analytical standard

Glucagon

Synonyms: Glukagon, HG-Factor, His-ser-glu(nh2)-gly-thr-phe-thr-ser-asp-tyr-ser-lys-tyr-leu-asp-ser-arg-arg-ala-glu(NH2)-asp-phe-val-glu(NH2)-trp-leu-met-asp(NH2)-thr, Hyperglycemic-Glycogenolytic Factor, His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr, Gvoke PFS, Baqsimi, Gvoke hypopen, Glucagen Hypokit, HSQGTFTSDYSKYLDSRRAQDFVQWLMNT, Human Glucagon, Glucagon, pig, Glucagon (1-29), Proglucagon (33-61), Glucagon, porcine, Glucagon 1555, Glucagon (human), Glucagon recombinant, Glucagon (swine), Glucagon (1-29), bovine, human, porcine, Bovine glucagon, Glucagon (dog), Glucagon (ox), Glucagon (Saimiri sciureus), Glucagon (Mesocricetus auratus)

Cat. No.: P-G044-001
CAS: 16941-32-5
Alternative CAS: 28270-04-4 (hydrochloride)
19179-82-9 (hydrochloride)
9007-92-5 (alternative CAS, same compound)
Formula: C₁₅₃H₂₂₅N₄₃O₄₉S
Molecular weight: 3482.80 g/mol
Category: Active ingredient (API)

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Characterisation level Level 1 Mass balanceFor small molecules, identity is confirmed by IR, MS, 1H-NMR and 13C-NMR, purity by HPLC (min. 95%) and assay by mass balance (min. 90%); for peptides and similar molecules, identity is confirmed by mass spectrometry (ESI-MS and MALDI-TOF) and IR, purity by HPLC (min. 95%) and assay by mass balance, reported for information only.* Level 2 Mass balance + qNMRFor small molecules, in addition to the Level 1 analyses, the assay is verified by qNMR, an orthogonal method independent of chromatography; for peptides and similar molecules, Level 2 is not available. Analytical documentation supporting qualification as an in-house primary standard under ICH Q7 (§11.17-11.18).

* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.

Quantity

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We reply within 24 hours with a quote and availability. CoA and SDS with every lot.

A 29-amino-acid peptide hormone made by the alpha cells of the pancreas, which raises blood sugar by releasing glucose from the liver; described in the early 1920s, it is used for severe hypoglycaemia and as a diagnostic aid in radiology.

Did you know?In the early 1920s Kimball and Murlin noticed that some pancreatic extracts raised blood sugar instead of lowering it, and named the substance responsible glucagon, from 'glucose agonist'.

The two levels compared

	Level 1 Mass balance	Level 2 Mass balance + qNMR
Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR)	✓	✓
HPLC purity (min. 95%)	✓	✓
Content by mass balance (min. 90%; peptides: for information only)*	✓	✓
Content verified by qNMR (small molecules only)	·	✓
Suitable to qualify it as an in-house primary standard (ICH Q7)	·	✓

What you receive

The analytical standard

Shipped under controlled temperature when the molecule requires it.

Certificate of analysis (CoA)

For every lot: identity, purity and assay, with the supporting spectra and chromatograms.

Safety data sheet (SDS)

Sent with every order.

Tracked shipment

Follow your shipment live, from our warehouse to your lab.

Pharmacopoeial standards available

The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.

Human glucagon CRSEP Y0000191

More products in the Glucagon family

Isotopically labelledGlucagon-d9 TrifluoroacetateCat. No. P-G044-002

Impurity(Asp-28)-Glucagon TetratrifluoroacetateCat. No. P-G044-003CAS 1037751-81-7

Impurity(Des-Thr5)-Glucagon TetratrifluoroacetateCat. No. P-G044-004CAS 1802078-27-8

Impurity(Des-Thr7)-Glucagon TetratrifluoroacetateCat. No. P-G044-005CAS 1802078-28-9

ImpurityGlucagon-like peptide I (human)(GLP-I,1-37) TrifluoroacetateCat. No. P-G044-022CAS 87805-34-3

ImpurityMet(O) 27 Glucagon TetratrifluoroacetateCat. No. P-G044-024CAS 75217-63-9

See all 7 products in the family

Frequently asked questions

Is mass balance always performed?

Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.

Can I ask for a different quantity?

Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.

Which level should I choose?

Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.

When will I get the quote?

Within 24 working hours, with price, availability and delivery time.

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