Structure not applicable: biological material
Impurity or related compound · Human Normal Immunoglobulin family
Pharmaceutical analytical standardHuman immunoglobulin for Fc function BRP
- Cat. No.
- P-H032-003
- CAS
- 9007-83-4
- Alternative CAS
- N/A
- Category
- Impurity or related compound
Family: Human Normal Immunoglobulin
A mixture of antibodies, mainly IgG, purified from the plasma of many donors: after first uses in the 1930s and intravenous formulations in the 1980s, it is used for primary immunodeficiencies, immune thrombocytopenic purpura and Kawasaki disease.
Did you know?In 1952 the physician Ogden Bruton described a boy unable to develop immunity to common childhood infections: it was the first description of agammaglobulinaemia, still treated today with immunoglobulin infusions.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Human immunoglobulin (molecular size) BRPEP Y0000488
- Human immunoglobulin for electrophoresis BRPEP H1000000
- Human immunoglobulin for fc function BRPEP Y0001966
More products in the Human Normal Immunoglobulin family
Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.