Active ingredientIdelalisibCat. No. P-I018-001CAS 870281-82-6
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Impurity or related compound · Idelalisib family
Pharmaceutical analytical standardIdelalisib Impurity 2
Synonyms: 3-Phenyl-2-[(1S)-1-(7H-purin-6-ylamino)propyl]quinazolin-4-one
- Cat. No.
- P-I018-010
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C22H19N7O
- Molecular weight
- 397.44 g/mol
- Category
- Impurity or related compound
Family: Idelalisib
An oral inhibitor of PI3K delta, an enzyme found in normal and malignant B lymphocytes. Approved in the United States in July 2014, it was the first drug of the PI3K inhibitor class; it is used mainly in chronic lymphocytic leukaemia.
Did you know?It works on two fronts: it switches off B-cell receptor signals and blocks the chemical calls, such as those of the CXCR4 and CXCR5 receptors, that guide these cells to their hideouts in the lymph nodes and bone marrow.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Idelalisib family
Active ingredientIdelalisibCat. No. P-I018-001CAS 870281-82-6
MetaboliteIdelalisib MetaboliteCat. No. P-I018-002
Isotopically labelledIdelalisib Metabolite-d5Cat. No. P-I018-004
Isotopically labelledIdelalisib-d5Cat. No. P-I018-005CAS 1830330-31-8
NitrosamineN-Nitroso IdelalisibCat. No. P-I018-006
ImpurityIdelalisib Impurity 1Cat. No. P-I018-007CAS 2044710-26-9
ImpurityIdelalisib INTCat. No. P-I018-008CAS 870281-86-0
Impurity2-amino-6-fluoro-N-phenylbenzamideCat. No. P-I018-009CAS 1417456-04-2Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.