Active ingredientLomitapideCat. No. P-L086-001CAS 182431-12-5
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Metabolite · Lomitapide family
Pharmaceutical analytical standardLomitapide Metabolite 1
- Cat. No.
- P-L086-004
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C37H36F3N3O2
- Molecular weight
- 611.71 g/mol
- Category
- Metabolite
Family: Lomitapide
An oral inhibitor of the MTP protein, which the liver uses to assemble and release VLDL lipoproteins. Approved in 2012 in the United States and in 2013 in Europe for homozygous familial hypercholesterolaemia, a rare inherited form of very high cholesterol.
Did you know?The idea came from abetalipoproteinaemia, a rare disease in which the MTP gene does not work and almost no LDL is made: Daniel Rader, at the University of Pennsylvania, proposed mimicking it with a drug.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Lomitapide family
Active ingredientLomitapideCat. No. P-L086-001CAS 182431-12-5
Active ingredientLomitapide MesylateCat. No. P-L086-002CAS 202914-84-9
MetaboliteLomitapide Carboxilic Acid MetaboliteCat. No. P-L086-003CAS 252361-04-9
MetaboliteLomitapide Metabolite 2Cat. No. P-L086-005CAS 791814-98-7
Isotopically labelledLomitapide-d8Cat. No. P-L086-006CAS 2459377-96-7
ImpurityLomitapide Impurity FCat. No. P-L086-007
ImpurityLomitapide M1Cat. No. P-L086-009CAS 182439-41-4
ImpurityLomitapide M1 HydrochlorideCat. No. P-L086-010CAS 1838769-21-3Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.