Pharmacopoeial impurityLoperamide EP Impurity ACat. No. P-L089-002CAS 1391052-94-0
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Active ingredient · Loperamide family
Pharmaceutical analytical standardLoperamide Hydrochloride
Synonyms: Imodium A-D, Arret, Imodium A-D EZ chews, Imodium advanced, Diaquitte, Diareze, Diocalm, Diocaps, Dioraleze, Entrocalm, Loperagen, Norimode, Normaloe, Difixn, Lodiar, Imodium classic, Anti Diarrheal, Medique Diamode, Diah-limit, Diarrhoea relief, Imodium instants, Marc Glassman, Gppe pack, Imodium liquicaps, Imodium ibs relief, Injoy diarrhea relief, Imodium instant melts, Leader Anti Diarrheal, Equate diarrhea control, Goodnow diarrhea relief, Sunmark Anti Diarrheal, Topcare Anti Diarrheal, Good Sense antidiarrheal, CareOne Diarrhea Control, Dg Health Anti Diarrheal, Private Label Distributor, Anti-Diarrheal, Circle K, Signature care anti diarrheal, Stomach Relief Anti Diarrheal, Anti-Diarrheal, CVP HEALTH, Handy Solutions Anti-Diarrheal, Lil Drug Store Anti-diarrheal, First Aid Direct Anti-Diarrheal, Good Neighbor Pharmacy Anti Diarrheal, Imodium, Suprasec, Maalox Anti-Diarrheal, Dissenten, Lopemid, Lopemin, Loperyl, Imosec, Tebloc, BLOX, BREK, Diamode, Imotil, Kao-Paverin, Diar-Aid, K-Pek II, Pepto Diarrhea Control
- Cat. No.
- P-L089-001
- CAS
- 34552-83-5
- Alternative CAS
- 53179-11-6 (free base)
- Formula
- C29H33ClN2O2·HCl
- Molecular weight
- 513.50 g/mol
- Category
- Active ingredient (API)
An antidiarrhoeal that acts on opioid receptors in the gut wall, slowing down its movements: synthesised in Belgium in 1969 and in use since the 1970s.
Did you know?Although it is a chemical relative of the opioids, at normal doses it does not reach the brain: a pump in the blood-brain barrier, P-glycoprotein, sends it straight back out.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Loperamide HydrochlorideBP 635
- Loperamide for system suitability CRSEP Y0002087
- Loperamide hydrochloride CRSEP L0750000
More products in the Loperamide family
Pharmacopoeial impurityLoperamide EP Impurity ACat. No. P-L089-002CAS 1391052-94-0
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Pharmacopoeial impurityLoperamide EP Impurity B ChlorideCat. No. P-L089-004
Pharmacopoeial impurityLoperamide EP Impurity CCat. No. P-L089-005CAS 39512-49-7
Pharmacopoeial impurityLoperamide EP Impurity DCat. No. P-L089-006CAS 37743-41-2
Pharmacopoeial impurityLoperamide EP Impurity ECat. No. P-L089-007CAS 1426322-82-8
Pharmacopoeial impurityLoperamide EP Impurity GCat. No. P-L089-008CAS 109572-89-6
Pharmacopoeial impurityLoperamide EP Impurity G HClCat. No. P-L089-009Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.