Active ingredientAminolevulinic AcidCat. No. P-A126-001CAS 106-60-5
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Pharmacopoeial impurity · Aminolevulinic Acid family
Pharmaceutical analytical standardMethylaminolevulinate EP Impurity C
Synonyms: Methyl-3-[5-(2-methoxycarbonylethyl)pyrazin-2-yl] Propionate, Dimethyl 3,3'-(pyrazine-2,5-diyl)dipropanoate, methyl 3-[5-(3-methoxy-3-oxopropyl)pyrazin-2-yl]propanoate, Dimethyl 3,3'-(pyrazine-2,5-diyl)dipropionate
- Cat. No.
- P-A126-003
- CAS
- 77479-01-7
- Alternative CAS
- N/A
- Formula
- C12H16N2O4
- Molecular weight
- 252.27 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Aminolevulinic Acid
A natural amino acid, the first building block of the pathway leading to haem in blood and, in plants, to chlorophyll: in medicine it is used in photodynamic therapy and, in the United States since 2017, to make malignant gliomas visible during surgery.
Did you know?The patient takes it by mouth before the operation: tumour cells turn it into protoporphyrin IX, which glows red to pink under violet-blue light of about 405 nm and guides the surgeon.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Methylaminolevulinate impurity C CRSEP Y0002279
More products in the Aminolevulinic Acid family
Active ingredientAminolevulinic AcidCat. No. P-A126-001CAS 106-60-5
Active ingredientAminolevulinic Acid HydrochlorideCat. No. P-A126-002CAS 5451-09-2
Isotopically labelledMethylaminolevulinate EP Impurity B-d2 HydrochlorideCat. No. P-A126-004CAS 187237-35-0
Impurity5-Aminolevulinic Acid Impurity 1Cat. No. P-A126-005CAS 1688598-83-5
Impurity5-Aminolevulinic Acid Impurity 2Cat. No. P-A126-006Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.