Active ingredientMetixene Hydrochloride MonohydrateCat. No. P-M105-001CAS 7081-40-5
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Pharmacopoeial impurity · Metixene family
Pharmaceutical analytical standardMetixene Hydrochloride EP Impurity B
Synonyms: Thioxanthone, thioxanthen-9-one, Thiaxanthenone, Thioxanthenone, Thiaxanthon, NSC 15912, NSC 658181, Thiaxanthone, Thioxanthene-9-one, Thioxanthene, 9-oxo-, Thioxanthone, 9-Oxothioxanthene, NSC 54677
- Cat. No.
- P-M105-003
- CAS
- 492-22-8
- Alternative CAS
- N/A
- Formula
- C13H8OS
- Molecular weight
- 212.27 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Metixene
An anticholinergic (antimuscarinic) drug with a thioxanthene structure, prepared in the late 1950s and patented in 1959: it is used for the symptoms of parkinsonism.
Did you know?Studies in animal models showed that it triggers incomplete autophagy in cancer cells: in mice it killed metastatic breast cancer cells and extended survival in the presence of brain metastases.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Thioxanthone CRSEP T1305000
More products in the Metixene family
Active ingredientMetixene Hydrochloride MonohydrateCat. No. P-M105-001CAS 7081-40-5
Pharmacopoeial impurityMetixene Hydrochloride EP Impurity ACat. No. P-M105-002CAS 261-31-4Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.