Pharmacopoeial impurityMetixene Hydrochloride EP Impurity ACat. No. P-M105-002CAS 261-31-4
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Active ingredient · Metixene family
Pharmaceutical analytical standardMetixene Hydrochloride Monohydrate
Synonyms: Methixene hydrochloride, Methixene HCl, Trest, Methixene hydrochloride monohydrate, Metixen, Tremonil, Methixene hydrochloride hydrate, Piperidine, 1-methyl-3-(9H-thioxanthen-9-ylmethyl)-, hydrochloride, monohydrate
- Cat. No.
- P-M105-001
- CAS
- 7081-40-5
- Alternative CAS
- 4969-02-2 (free base)
- 1553-34-0 (anhydrous form)
- Formula
- C20H23NS·HCl·H2O
- Molecular weight
- 363.94 g/mol
- Category
- Active ingredient (API)
An anticholinergic (antimuscarinic) drug with a thioxanthene structure, prepared in the late 1950s and patented in 1959: it is used for the symptoms of parkinsonism.
Did you know?Studies in animal models showed that it triggers incomplete autophagy in cancer cells: in mice it killed metastatic breast cancer cells and extended survival in the presence of brain metastases.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Metixene hydrochloride CRSEP M1808000
More products in the Metixene family
Pharmacopoeial impurityMetixene Hydrochloride EP Impurity ACat. No. P-M105-002CAS 261-31-4
Pharmacopoeial impurityMetixene Hydrochloride EP Impurity BCat. No. P-M105-003CAS 492-22-8Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
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