Active ingredientDimethyl FumarateCat. No. P-D130-001CAS 624-49-7
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Stable isotope labelled · Dimethyl Fumarate family
Pharmaceutical analytical standardMonomethyl Fumarate-d5
Synonyms: Fumaric Acid Monomethyl Ester-d5
- Cat. No.
- P-D130-005
- CAS
- 1616345-45-9
- Alternative CAS
- 2756-87-8 (unlabelled form)
- 44836-34-2 (unlabelled form)
- Formula
- C5HD5O4
- Molecular weight
- 135.13 g/mol
- Category
- Stable isotope labelled
Family: Dimethyl Fumarate
An ester of fumaric acid taken by mouth for psoriasis, in Germany since 1994 in a mixture with other fumarates, and for relapsing multiple sclerosis, in the United States since 2013 and in Europe since 2014; in the body it becomes monomethyl fumarate.
Did you know?It all began with a hypothesis by the German chemist Walter Schweckendiek, who in 1959 blamed psoriasis on a disturbance of fumaric acid in the Krebs cycle: the theory did not hold up, the treatment did.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Dimethyl Fumarate family
Active ingredientDimethyl FumarateCat. No. P-D130-001CAS 624-49-7
Pharmacopoeial impurityDimethyl Fumarate USP Related Compound ACat. No. P-D130-002CAS 2756-87-8
Isotopically labelledDimethyl-d6 FumarateCat. No. P-D130-003CAS 66487-95-4
Isotopically labelledMonomethyl Fumarate-d3Cat. No. P-D130-004CAS 1616345-41-5
ImpurityBis(2-ethylhexyl) FumarateCat. No. P-D130-006CAS 141-02-6
ImpurityDiisopropyl FumarateCat. No. P-D130-007CAS 7283-70-7
ImpurityDimethyl Fumarate DimerCat. No. P-D130-008CAS 14495-41-1
ImpurityDimethyl Fumarate Impurity 1Cat. No. P-D130-009CAS 63119-87-9Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.