Active ingredientFurosemideCat. No. P-F135-001CAS 54-31-9
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Nitrosamine · Furosemide family
Pharmaceutical analytical standardN-Nitroso Furosemide
Synonyms: 4-Chloro-2-[furan-2-ylmethyl(nitroso)amino]-5-sulfamoylbenzoic acid
- Cat. No.
- P-F135-014
- CAS
- 2708280-93-5
- Alternative CAS
- N/A
- Formula
- C12H10ClN3O6S
- Molecular weight
- 359.74 g/mol
- Category
- Nitrosamine
Family: Furosemide
A loop diuretic patented in 1959 and approved in 1964: in the kidney it blocks the sodium-potassium-chloride cotransporter and makes the body excrete water and salt. It is used for oedema and hypertension and is on the WHO List of Essential Medicines.
Did you know?Loop diuretics owe their name to the loop of Henle, the part of the kidney where they act, named after its discoverer, the German anatomist Friedrich Gustav Jakob Henle.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Furosemide family
Active ingredientFurosemideCat. No. P-F135-001CAS 54-31-9
Pharmacopoeial impurityFurosemide EP Impurity ACat. No. P-F135-002CAS 4818-59-1
Pharmacopoeial impurityFurosemide EP Impurity BCat. No. P-F135-003CAS 2736-23-4
Pharmacopoeial impurityFurosemide EP Impurity CCat. No. P-F135-004CAS 3086-91-7
Pharmacopoeial impurityFurosemide EP Impurity DCat. No. P-F135-005CAS 5046-19-5
Pharmacopoeial impurityFurosemide EP Impurity FCat. No. P-F135-006CAS 4793-38-8
MetaboliteFurosemide acyl glucuronideCat. No. P-F135-007CAS 72967-59-0
Isotopically labelledFurosemide Impurity 21 Sodium Salt-d10Cat. No. P-F135-009Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.