Active ingredientNeostigmineCat. No. P-N035-001CAS 59-99-4
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Pharmacopoeial impurity · Neostigmine family
Pharmaceutical analytical standardNeostigmine EP Impurity A Metilsulfate
Synonyms: 3-hydroxy-N,N,N-trimethylbenzenaminiummethylsulfate, Benzenaminium, 3-hydroxy-N,N,N-trimethyl-, methyl sulfate (1:1)
- Cat. No.
- P-N035-006
- CAS
- 4312-54-3
- Alternative CAS
- 3483-84-9 (free base)
- 2498-27-3 (hydroiodide)
- 1620-19-5 (hydrobromide)
- Formula
- C9H14NO·CH3O4S
- Molecular weight
- 263.31 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Neostigmine
A cholinesterase inhibitor synthesised in 1931 by Aeschlimann and Reinert, a simplified version of physostigmine: it is used for myasthenia gravis and to reverse the effect of muscle relaxants at the end of anaesthesia.
Did you know?In 1934 Scottish physician Mary Walker found that physostigmine briefly relieved myasthenia gravis, 'the miracle at St Alfege's', named after her London hospital; in 1935 she showed the same benefit with neostigmine.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Neostigmine family
Active ingredientNeostigmineCat. No. P-N035-001CAS 59-99-4
Active ingredientNeostigmine BromideCat. No. P-N035-002CAS 114-80-7
Pharmacopoeial impurityNeostigmine EP Impurity ACat. No. P-N035-003CAS 3483-84-9
Pharmacopoeial impurityNeostigmine EP Impurity A BromideCat. No. P-N035-004CAS 1620-19-5
Pharmacopoeial impurityNeostigmine EP Impurity A IodideCat. No. P-N035-005CAS 2498-27-3
Pharmacopoeial impurityNeostigmine EP Impurity BCat. No. P-N035-007CAS 99-07-0
Pharmacopoeial impurityNeostigmine EP Impurity CCat. No. P-N035-008CAS 16088-19-0
Isotopically labelledNeostigmine Bromide EP Impurity C-d6Cat. No. P-N035-009CAS 2470126-73-7Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.