Active ingredientNetupitantCat. No. P-N042-001CAS 290297-26-6
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Impurity or related compound · Netupitant family
Pharmaceutical analytical standardNetupitant carbamate Impurity
Synonyms: Methyl (6-(4-Methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbaMate
- Cat. No.
- P-N042-017
- CAS
- 342417-02-1
- Alternative CAS
- N/A
- Formula
- C19H24N4O2
- Molecular weight
- 340.43 g/mol
- Category
- Impurity or related compound
Family: Netupitant
An NK1 receptor antagonist that blocks substance P, used in a fixed combination with palonosetron to prevent chemotherapy-induced nausea and vomiting; the combination was approved in the United States in 2014 and in Europe in 2015.
Did you know?It is long-acting, with a half-life of about 88 hours: it protects both in the first 24 hours after chemotherapy and in the delayed phase, up to five days later, while palonosetron mainly covers the acute phase.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Netupitant family
Active ingredientNetupitantCat. No. P-N042-001CAS 290297-26-6
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ImpurityNetupitant Impurity 1Cat. No. P-N042-009CAS 2920686-87-7
ImpurityNetupitant Impurity 2Cat. No. P-N042-010CAS 1314722-26-3
ImpurityNetupitant Impurity 3Cat. No. P-N042-011CAS 289686-70-0Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.