Active ingredient · Nicotinamide family

Pharmaceutical analytical standard

Nicotinamide

Synonyms: pyridine-3-carboxamide, Niacinamide, Nicotinic acid amide, Aminicotin, Amixicotyn, Benicot, Dipegyl, Nicofort, Papulex, Nicotinic amide, Delonin amide, Pelonin amide, Inovitan PP, Nicotilamide, Nicotylamide, Endobion, Hansamid, Nicamindon, Nicobion, Nicovitol, Nikotinamid, Niozymin, Savacotyl, Pelmine, Austrovit PP, Vi-Nicotyl, Amnicotin, Nicomidol, Nicosylamide, Nicotamide, Nicotililamido, Nicovitina, Nicozymin, Niocinamide, Niacevit, Niamide, Nicamina, Nicasir, Nicogen, Nicotol, Nicovit, Nicota, Nicosan 2, Niko-tamin, Pyridine-3-carboxylic acid amide, Nandervit-N, Nicotine acid amide, Niavit PP, Nicotine amide, Nikotinsaeureamid, beta-Pyridinecarboxamide, Pyridine, 3-carbamoyl-, Nicotylamidum, Nicotinsaureamid, Factor pp, m-(Aminocarbonyl)pyridine, Nicovel, Pelmin, Witamina PP, PP-Faktor, Amid kyseliny nikotinove, Amide PP, Dipigyl, Niacinamid, NSC 13128, NSC 27452, Vitamin B 3, Niacin (as niacinamide), Skin, Creankojicaid, Nicosedine, Phytokerating, Freederm, Nicamid, Niatin, Trstay, Nicam, Ginger Germinal, Organic Miracle, Tanning Mousse, Tratay Collagen, Trestay Retinol, Trstay Avocado, Trstay Collagen, Trstay Firming, Trstay Gardenia, Trstay Retinol, Ultra Whitening, Infinite Aloe, Layender Oil, Minyak Kemiri, Rice Ceramide, Sleeping Mask, Stretch Marks, Men cheam, Facial Oil, Ginger King, Glycerin Essence, Smooth Skincream, Snail Mucin, Trstay Bala, Trstay Pferdebal, CellExosome HR, CellExosome SB, Age Renew, Body Balm, Dr Rashel, Bard Growth Oil, Ginseng Whitening, Pure Jojoba Oil, Retinol HA, Rice Moisturizing, Vitamin E Serum, Dark Spot Wand, Sadoerbuttockscream, Super Aaua Max, Super Aqua Max, Dr.Jucre Rebirth, Herbal Gray Hair, Pro Dark Spot, Trasay Vitamin C, Trstay Dark Soot, Trstay Eye Serum, Trstay Lift Firm, Trstay Skin Care, Trstay V-Face, Trstay Vitamin C, Ganoderma Nutrient, Tea Tree Oll, Trstay Moisturizer, Royal GinsengCream, TOAS Rejuvenation, Collagen hyaluronic, Emblem Clean Skin, Hip Lift Up, Kojic Acid Rmeric, Pre Wax Treatment, Proven By Science, Scar Repair Gream, Trstay Acne Serum, Trstay Clean Skin, Avocado Moisturizer, Nails Essenceliquid, Revitaliftlaser X3, Rosehip Moisturizer, Trstay Blemishcream, Trstay Laboratoires, Beard Oil Contains, Costem cell 5 N, Plump Buttocks Oil, Retinol Night Lift, Royal GinsengLotion, Trstay Rosehip Oil, Trstay Sakur Serum, Trstay Snow Bleach, TURMERICFaceCream, Jours Huile minceur, AAPE Skin Ampoule, CellExosome HE HR, Dark Spot Corrector, Fantastic LightCream, Ginger Essental Oil, Massagehssential Oil, Niacinamide Malaysia, Rejuvenating Day Cr, Rosemary Hair Serum, Royal Ginseng Toner, Trstay Facial Serum, Trstay Firm Tighten, Trstay Hair Removal, Trstay Turmeric Oil, For All Skin Types, Butt Enhancement Oil, Crepe Corrector Booy, Crepe Skin Treatment, Lavender Massage Oil, Pore Minimizer Serum, Relaxing Massage Oil, Retinol Facial Serum, Trstay Hair Membrane, Trstay Peeling Serum, Trstay Retinol Serum, Trstay Ultra Glowing, Krshum Ginger 7Days, Day Night Face Lift, JamaicanBlackCastorOil, PureVita Vitamin B3, Tratay Coffee extract, Vita C Bright Serum, Vita C Bright Toner, Niacinamide Face Mask, Rice Moisturizingcream, Royal Ginseng Essence, Trstay Breast Enhance, Trstay Coffee Extract, Ultra Whitening Ample

Cat. No.: P-N051-001
CAS: 98-92-0
Alternative CAS: 10030-92-9 (hydrobromide)
3726-23-6 (hydroiodide)
25334-23-0 (hydrochloride)
917925-73-6 (hydrate)
11032-50-1 (alternative CAS, same compound)
1255150-40-3 (alternative CAS, same compound)
Formula: C₆H₆N₂O
Molecular weight: 122.13 g/mol
Category: Active ingredient (API)

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Characterisation level Level 1 Mass balanceFor small molecules, identity is confirmed by IR, MS, 1H-NMR and 13C-NMR, purity by HPLC (min. 95%) and assay by mass balance (min. 90%); for peptides and similar molecules, identity is confirmed by mass spectrometry (ESI-MS and MALDI-TOF) and IR, purity by HPLC (min. 95%) and assay by mass balance, reported for information only.* Level 2 Mass balance + qNMRFor small molecules, in addition to the Level 1 analyses, the assay is verified by qNMR, an orthogonal method independent of chromatography; for peptides and similar molecules, Level 2 is not available. Analytical documentation supporting qualification as an in-house primary standard under ICH Q7 (§11.17-11.18).

* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.

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We reply within 24 hours with a quote and availability. CoA and SDS with every lot.

The most common form of vitamin B3 (niacin). In the body it is part of NAD, a coenzyme essential for obtaining energy from sugars and fats; in 1937 the biochemist Conrad Elvehjem showed that it cures pellagra in dogs, paving the way for curing the disease in humans.

Did you know?Its name comes from nicotine: nicotinic acid, the twin compound from which nicotinamide derives, was first produced from nicotine long before its role as a vitamin was known.

The two levels compared

	Level 1 Mass balance	Level 2 Mass balance + qNMR
Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR)	✓	✓
HPLC purity (min. 95%)	✓	✓
Content by mass balance (min. 90%; peptides: for information only)*	✓	✓
Content verified by qNMR (small molecules only)	·	✓
Suitable to qualify it as an in-house primary standard (ICH Q7)	·	✓

What you receive

The analytical standard

Shipped under controlled temperature when the molecule requires it.

Certificate of analysis (CoA)

For every lot: identity, purity and assay, with the supporting spectra and chromatograms.

Safety data sheet (SDS)

Sent with every order.

Tracked shipment

Follow your shipment live, from our warehouse to your lab.

Pharmacopoeial standards available

The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.

NicotinamideBP 460
Nicotinamide CRSEP N0600000

More products in the Nicotinamide family

Pharmacopoeial impurityNicotinamide EP Impurity CCat. No. P-N051-002CAS 1452-77-3

Pharmacopoeial impurityNicotinamide EP Impurity ECat. No. P-N051-003CAS 1986-81-8

MetaboliteNicotinamide Metabolite 1Cat. No. P-N051-004

Isotopically labelledbeta-Nicotinamide Mononucleotide-13C5Cat. No. P-N051-006

Isotopically labelledbeta-Nicotinamide Mononucleotide-d4Cat. No. P-N051-009

Isotopically labelledNicotinamide Riboside-d4 TriflateCat. No. P-N051-013

Isotopically labelledNicotinamide-d4Cat. No. P-N051-014CAS 347841-88-7

Impurity1,2-Isonicotinyl HydrazineCat. No. P-N051-015CAS 4329-75-3

See all 26 products in the family

Frequently asked questions

Is mass balance always performed?

Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.

Can I ask for a different quantity?

Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.

Which level should I choose?

Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.

When will I get the quote?

Within 24 working hours, with price, availability and delivery time.

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