Active ingredientNortriptyline HydrochlorideCat. No. P-N095-001CAS 894-71-3
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Pharmacopoeial impurity · Nortriptyline family
Pharmaceutical analytical standardNortriptyline EP Impurity J
Synonyms: Amitriptyline N-Oxide, Amitriptylinoxide, Equilibrin, Ambivalon, Amitriptilinoxido, Amitriptylinoxyde, Amitriptyline oxide, Amitriptylinoxidum, N,N-dimethyl-3-(tricyclo(9.4.0.0^(3,8))pentadeca-1(15),3,5,7,11,13-hexaen-2-ylidene)propanamine oxide, Amioxid-neuraxpharm, Amitriptylinoxid, Amitryptiline-N-oxide, Amitryptyline-n-oxide
- Cat. No.
- P-N095-006
- CAS
- 4317-14-0
- Alternative CAS
- 4290-60-2 (hydrochloride)
- Formula
- C20H23NO
- Molecular weight
- 293.41 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Nortriptyline
A tricyclic antidepressant introduced in 1963: it is an active metabolite of amitriptyline, which the liver converts into it by removing a methyl group, and it works mainly by blocking the reuptake of noradrenaline.
Did you know?Besides depression, it has been studied successfully as an aid to stop smoking, an unexpected use for an antidepressant.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Nortriptyline family
Active ingredientNortriptyline HydrochlorideCat. No. P-N095-001CAS 894-71-3
Pharmacopoeial impurityNortriptyline EP Impurity B HydrochlorideCat. No. P-N095-002CAS 438-59-5
Pharmacopoeial impurityNortriptyline EP Impurity GCat. No. P-N095-003CAS 16234-88-1
Pharmacopoeial impurityNortriptyline EP Impurity HCat. No. P-N095-004CAS 24755-73-5
Pharmacopoeial impurityNortriptyline EP Impurity J HydrochlorideCat. No. P-N095-005CAS 4290-60-2
MetaboliteNortriptyline N-GlucuronideCat. No. P-N095-007
Isotopically labelledN-Nitrosonortriptyline-D3Cat. No. P-N095-008
Isotopically labelledNortriptyline-d3 HydrochlorideCat. No. P-N095-010CAS 203784-52-5Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.