Active ingredientOndansetronCat. No. P-O023-001CAS 99614-02-5
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Pharmacopoeial impurity · Ondansetron family
Pharmaceutical analytical standardOndansetron EP Impurity F
Synonyms: 2-Methylimidazole, 2-methyl-1H-imidazole, Curezol-2mz-p, Imicure-ami 2, Epicure-mi 2, Epikure-mi 2, NSC 21394, Imidazole, 2-methyl-, Ondansetron impurity F, Methylimidazol, Methylimidazole, 2-
- Cat. No.
- P-O023-010
- CAS
- 693-98-1
- Alternative CAS
- 55514-31-3 (hydrochloride)
- 59061-53-9 (zinc salt)
- Formula
- C4H6N2
- Molecular weight
- 82.11 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Ondansetron
A selective serotonin 5-HT3 receptor antagonist developed in London in the mid-1980s and approved in the United States in 1991. It prevents nausea and vomiting caused by chemotherapy and surgery and is on the WHO List of Essential Medicines.
Did you know?Chemotherapy makes enterochromaffin cells in the gut release serotonin, which stimulates the vagus nerve and triggers the vomiting reflex: ondansetron works mainly by blocking this signal in the periphery.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Ondansetron impurity F CRSEP Y0001320
More products in the Ondansetron family
Active ingredientOndansetronCat. No. P-O023-001CAS 99614-02-5
Active ingredientOndansetron HClCat. No. P-O023-002CAS 99614-01-4
Active ingredientOndansetron Hydrochloride DihydrateCat. No. P-O023-003CAS 103639-04-9
Pharmacopoeial impurityImidazoleCat. No. P-O023-004CAS 288-32-4
Pharmacopoeial impurityOndansetron EP Impurity A HydrochlorideCat. No. P-O023-005CAS 119812-29-2
Pharmacopoeial impurityOndansetron EP Impurity ACat. No. P-O023-006CAS 153139-56-1
Pharmacopoeial impurityOndansetron EP Impurity BCat. No. P-O023-007CAS 1076198-52-1
Pharmacopoeial impurityOndansetron EP Impurity CCat. No. P-O023-008CAS 27387-31-1Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.