Active ingredientSimvastatinCat. No. P-S045-001CAS 79902-63-9
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Impurity or related compound · Simvastatin family
Pharmaceutical analytical standardOxo Simvastatin
- Cat. No.
- P-S045-035
- CAS
- 1426939-44-7
- Alternative CAS
- N/A
- Formula
- C25H36O5
- Molecular weight
- 416.56 g/mol
- Category
- Impurity or related compound
Family: Simvastatin
A semi-synthetic statin that lowers cholesterol by blocking the enzyme HMG-CoA reductase, first approved in Sweden in 1988 and used to prevent heart attack, stroke and other cardiovascular disease.
Did you know?It derives from lovastatin, discovered in 1978 in the fermentation broth of the fungus Aspergillus terreus: a small change to the side chain makes it about two and a half times more active on the enzyme.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Simvastatin family
Active ingredientSimvastatinCat. No. P-S045-001CAS 79902-63-9
Pharmacopoeial impuritySimvastatin EP Impurity KCat. No. P-S045-002CAS 2731620-64-5
Pharmacopoeial impuritySimvastatin EP Impurity A (as Sodium Salt)Cat. No. P-S045-004CAS 101314-97-0
Pharmacopoeial impuritySimvastatin EP Impurity A (as Ammonium Salt)Cat. No. P-S045-005CAS 139893-43-9
Pharmacopoeial impuritySimvastatin EP Impurity BCat. No. P-S045-006CAS 145576-25-6
Pharmacopoeial impuritySimvastatin EP Impurity A Calcium SaltCat. No. P-S045-007CAS 151006-18-7
Pharmacopoeial impuritySimvastatin EP Impurity CCat. No. P-S045-008CAS 210980-68-0
Pharmacopoeial impuritySimvastatin EP Impurity DCat. No. P-S045-009CAS 476305-24-5Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.