Active ingredientPhenazoneCat. No. P-P072-001CAS 60-80-0
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Pharmacopoeial impurity · Phenazone family
Pharmaceutical analytical standardPhenazone EP Impurity A
Synonyms: 5-methyl-2-phenyl-4H-pyrazol-3-one, Edaravone, Radicut, Norphenazone, Developer Z, Methylphenylpyrazolone, Norantipyrine, C.I. Developer 1, Phenylmethylpyrazolone, Radicava, Colorex pmp, Jarocol pmp, NSC 2629, NSC 26139, Monopyrazolone, Edaravona, Edaravone (USAN/JP18/INN), Pharmakon1600-01503635, NSC 758622, 5-Methyl-2-phenyl-1H-pyrazol-3(2H)-one, 5-methyl-2-phenyl-1H-pyrazol-3-one, N-Demethylantipyrine, Edarabone, Teneligliptin impurity N1, Edaravone Related Compound, Pyrazole, 2,3-dihydro-5-methyl-3-oxo-2-phenyl-, Pyrazole, 2,5-dihydro-3-methyl-5-oxo-1-phenyl-
- Cat. No.
- P-P072-010
- CAS
- 89-25-8
- Alternative CAS
- 19735-89-8 (alternative CAS, same compound)
- Formula
- C10H10N2O
- Molecular weight
- 174.20 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Phenazone
One of the first synthetic drugs in history: an analgesic, antipyretic and anti-inflammatory synthesised by Ludwig Knorr in the early 1880s and patented in 1883. It is still found, for example, in ear drops.
Did you know?When it was patented, in 1883, there were very few synthetic medicines on the market, among them chloral hydrate, trimethylamine and iodol.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Phenazone impurity A CRSEP Y0001138
More products in the Phenazone family
Active ingredientPhenazoneCat. No. P-P072-001CAS 60-80-0
ImpurityNitroso AntipyrineCat. No. P-P072-002CAS 885-11-0
Impurity4-Formyl Methylamino AntipyrineCat. No. P-P072-003CAS 1672-59-9
Impurity4-Hydroxy AntipyrineCat. No. P-P072-004CAS 1672-63-5
Impurity4-Hydroxy Antipyrine Sulfate Ammonium SaltCat. No. P-P072-005
ImpurityPhenazone Impurity 2Cat. No. P-P072-008
ImpurityAntipyrine-4-PeroxideCat. No. P-P072-009CAS 69124-27-2Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.