Active ingredientChlorambucilCat. No. P-C128-001CAS 305-03-3
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Impurity or related compound · Chlorambucil family
Pharmaceutical analytical standardPhenylacetic Acid Mustard
Synonyms: 4-(Bis(2-chloroethyl)amino)benzeneacetic acid, 2-[4-[bis(2-chloroethyl)amino]phenyl]acetic acid, Phenacid, Phenylacetic mustard, PAAM, Benzeneacetic acid, 4-(bis(2-chloroethyl)amino)-, p-(N,N-bis(2-chloroethyl)amino)phenylacetic acid, Chlorphenacil, Chlorphenacyl, N,N-Bis(2-chloroethyl)-p-aminophenylacetic acid, Khlorfenatsil, p-N,N-(Dichloroethyl)aminophenylacetic acid, N,N-Bis(chloroethyl)-p-aminophenylacetic acid, p-(N,N-Di(2-chloroethyl)amino)phenylacetic acid, Acetic acid, (p-(bis(2-chloroethyl)amino)phenyl)-, ACETIC ACID, 2-(p-(BIS(2-CHLOROETHYL)AMINO)PHENYL)-, Bis(2-chloroethyl)aminobenzeneacetic acid, 4-
- Cat. No.
- P-C128-015
- CAS
- 10477-72-2
- Alternative CAS
- N/A
- Formula
- C12H15Cl2NO2
- Molecular weight
- 276.16 g/mol
- Category
- Impurity or related compound
Family: Chlorambucil
An alkylating agent of the nitrogen mustard family, synthesised in 1953 by Everett, Roberts and Ross and approved in the United States in 1957: it is taken by mouth for chronic lymphocytic leukaemia and some lymphomas.
Did you know?It belongs to the 'aromatic' mustards, which react with DNA more slowly than the first nitrogen mustards: this makes them less toxic and allows them to be taken by mouth.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Chlorambucil family
Active ingredientChlorambucilCat. No. P-C128-001CAS 305-03-3
Pharmacopoeial impurityChlorambucil EP Impurity ACat. No. P-C128-002CAS 27171-89-7
Pharmacopoeial impurityChlorambucil EP Impurity BCat. No. P-C128-003CAS 116505-53-4
Pharmacopoeial impurityChlorambucil EP Impurity CCat. No. P-C128-004
Pharmacopoeial impurityChlorambucil EP Impurity DCat. No. P-C128-005CAS 94236-91-6
Pharmacopoeial impurityChlorambucil EP Impurity ECat. No. P-C128-006CAS 1988791-13-4
Pharmacopoeial impurityChlorambucil EP Impurity FCat. No. P-C128-007
Pharmacopoeial impurityChlorambucil EP Impurity GCat. No. P-C128-008CAS 178481-89-5Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.