Active ingredient · Polidocanol family

Pharmaceutical analytical standard

Polidocanol

Synonyms: Nonaethylene Glycol Monododecyl Ether, Asclera, Aethoxy-sklerol, Nonaethylene glycol monolauryl ether, Varithena, Macrogol 9 lauryl ether, Dodecyl nonaoxyethylene ether, Dodecylnonaoxyethylene glycol monoether, Lauromacrogols, Laureths, Laureth 1, Laureth 7, Nikkol bl-9ex, Polyoxyethylenedodecyl Ethers, Polyoxyethylene Lauryl Ethers, Marlipal 24/90, Ether, Polyoxyethylene Lauryl, Polyoxyethylene 4 dodecyl Ether, Polyoxyethylene 9-lauryl Ethers, Ether, Polyoxyethylene 9-lauryl, Dodecyl Ethyleneglycol Monoethers, Tetraethyleneglycol Lauryl Ethers, Ether, Polyoxyethylene-4-dodecyl, Ether, Tetraethyleneglycol Lauryl, Ethyleneglycol Monoether, Dodecyl, Lauryl Ether, Tetraethyleneglycol, Monoether, Dodecyl Ethyleneglycol, Polyethylene Glycol 7 lauryl Ether, Ether, Polyethylene Glycol-7-lauryl, Nonaethyleneglycol Monododecyl Ethers, Polyethylene Glycol-7-lauryl Ethers, Ether, Nonaethyleneglycol Monododecyl, Monododecyl Ether, Nonaethyleneglycol, Dodecylnonaglycol, Genapol(r) x-080, Nonaoxyethylene monododecyl ether, Dodecyl nona ethylene glycol ether, POELE, Tridecyl alcohol ethoxylate, Lauromacrogol 450, Polyoxyethylen lauryl ether, Lauromacrogol 400 (ep monograph), Polyethylene glycol monolauryl ether (n=9), Nonaethylene glycol monododecyl ether, nonionic surfactant

Cat. No.: P-P151-001
CAS: 3055-99-0
Alternative CAS: 9043-30-5 (alternative CAS, same compound)
9002-92-0 (alternative CAS, same compound)
Formula: C₃₀H₆₂O₁₀
Molecular weight: 582.82 g/mol
Category: Active ingredient (API)

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Characterisation level Level 1 Mass balanceFor small molecules, identity is confirmed by IR, MS, 1H-NMR and 13C-NMR, purity by HPLC (min. 95%) and assay by mass balance (min. 90%); for peptides and similar molecules, identity is confirmed by mass spectrometry (ESI-MS and MALDI-TOF) and IR, purity by HPLC (min. 95%) and assay by mass balance, reported for information only.* Level 2 Mass balance + qNMRFor small molecules, in addition to the Level 1 analyses, the assay is verified by qNMR, an orthogonal method independent of chromatography; for peptides and similar molecules, Level 2 is not available. Analytical documentation supporting qualification as an in-house primary standard under ICH Q7 (§11.17-11.18).

* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.

Quantity

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We reply within 24 hours with a quote and availability. CoA and SDS with every lot.

A non-ionic surfactant made from dodecanol (lauromacrogol), used as a local anaesthetic and anti-itch agent in creams and, by injection, as a sclerosant for varicose and spider veins of the legs; approved in the United States since 2010.

Did you know?In cosmetics the same molecule is known as laureth-9: a chain of twelve carbon atoms joined to nine ethylene oxide units.

The two levels compared

	Level 1 Mass balance	Level 2 Mass balance + qNMR
Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR)	✓	✓
HPLC purity (min. 95%)	✓	✓
Content by mass balance (min. 90%; peptides: for information only)*	✓	✓
Content verified by qNMR (small molecules only)	·	✓
Suitable to qualify it as an in-house primary standard (ICH Q7)	·	✓

What you receive

The analytical standard

Shipped under controlled temperature when the molecule requires it.

Certificate of analysis (CoA)

For every lot: identity, purity and assay, with the supporting spectra and chromatograms.

Safety data sheet (SDS)

Sent with every order.

Tracked shipment

Follow your shipment live, from our warehouse to your lab.

More products in the Polidocanol family

Impurity3,6,9,12,15,18-Hexaoxadotriacontan-1-olCat. No. P-P151-004CAS 5157-04-0

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Impurity3,6,9,12,15-Pentaoxaheptacosan-1-olCat. No. P-P151-006CAS 3055-95-6

Impurity3,6,9,12-Tetraoxatetracosan-1-olCat. No. P-P151-007CAS 5274-68-0

ImpurityLaureth-12Cat. No. P-P151-008CAS 3056-00-6

ImpurityPolidocanol Impurity 1Cat. No. P-P151-009

ImpurityPolidocanol Impurity 2Cat. No. P-P151-010

ImpurityPolidocanol Impurity 3Cat. No. P-P151-011CAS 54350-53-7

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Frequently asked questions

Is mass balance always performed?

Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.

Can I ask for a different quantity?

Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.

Which level should I choose?

Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.

When will I get the quote?

Within 24 working hours, with price, availability and delivery time.

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