Active ingredientPralidoximeCat. No. P-P162-001CAS 6735-59-7
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Active ingredient · Pralidoxime family
Pharmaceutical analytical standardPralidoxime Chloride
Synonyms: Protopam chloride, Protopam, Pralidoxine chloride, Pyridine-2-aldoxime methochloride, Pyridinium, 2-((hydroxyimino)methyl)-1-methyl-, chloride, ComboPen, Pyridinium aldoxime methochloride, N-Methylpyridine-2-aldoxime chloride, N-Methylpyridinium chloride 2-aldoxime, N-Methylpyridinium-2-aldoxime chloride, Pyridinium, 2-((hydroxyimino)methyl)-1-methyl-, chloride (E)-, N-Metylpyridinium-2-aldoxime chloride, Pralidoximchlorid, Pyridinium, chloride, oxime, Pyridinium, 2-formyl-1-methyl-, chloride, oxime, (E)-Pralidoxime Chloride, Atnaa component pralidoxime chloride, Duodote component pralidoxime chloride, Pralidoxime chloride (USP-RS), Pralidoxime chloride (autoinjector), Pralidoxime chloride component of atnaa, Pralidoxime chloride component of duodote
- Cat. No.
- P-P162-002
- CAS
- 51-15-0
- Alternative CAS
- 6735-59-7 (free base)
- 25615-00-3 (free base)
- 14018-51-0 (hydrobromide)
- 94-63-3 (hydroiodide)
- 1200-55-1 (other salt)
- 14018-50-9 (alternative CAS, same compound)
- Formula
- C7H9N2O·Cl
- Molecular weight
- 172.61 g/mol
- Category
- Active ingredient (API)
Family: Pralidoxime
An antidote for organophosphate pesticide poisoning, synthesised in the mid-1950s at Columbia University in New York by Irwin Wilson and Sara Ginsburg: it is an oxime that pulls the phosphate off acetylcholinesterase and reactivates the enzyme, and is used together with atropine.
Did you know?It all began with an observation in 1951: Wilson noticed that a very simple molecule, hydroxylamine, could reactivate the blocked enzyme, and from there he looked for more powerful reactivators.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Pralidoxime family
Active ingredientPralidoximeCat. No. P-P162-001CAS 6735-59-7
Impurity(Z)-Pralidoxime ChlorideCat. No. P-P162-004CAS 13698-37-8
Impurity2-Carbamoyl-N-methylpyridinium MethanesulfonateCat. No. P-P162-005CAS 87141-87-5
Impurity2-Carboxy-N-methylpyridinium IodideCat. No. P-P162-006CAS 3785-04-4
Active ingredientPralidoxime Methyl SulphateCat. No. P-P162-007CAS 1200-55-1Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.