Pharmacopoeial impurityPrimidone EP Impurity A (as Hydrate)Cat. No. P-P190-002CAS 80866-90-6
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Active ingredient · Primidone family
Pharmaceutical analytical standardPrimidone
Synonyms: 5-ethyl-5-phenyl-1,3-diazinane-4,6-dione, Primaclone, Mysoline, Lepimidin, Lepsiral, Liskantin, Milepsin, Mylepsin, Mysedon, Primakton, Hexadiona, Prilepsin, Primoline, Prysoline, Resimatil, Majsolin, Misolyne, Mizolin, Neurosyn, Cyral, Midone, Primacone, Desoxyphenobarbitone, Pyrimidone Medi-pets, Hexamidine (the antispasmodic), NSC 41701, Myidone, Misodine, Mizodin, Sertan, Mylepsinum, Medi-Pets, Primacione, Pharmakon1600-01500501, NSC 757291
- Cat. No.
- P-P190-001
- CAS
- 125-33-7
- Alternative CAS
- 25717-89-9 (sodium salt)
- Formula
- C12H14N2O2
- Molecular weight
- 218.26 g/mol
- Category
- Active ingredient (API)
An anticonvulsant related to the barbiturates: its efficacy was shown in 1949 by Yule Bogue and in 1950 it came onto the market in the United Kingdom and Germany; today it is also used for essential tremor.
Did you know?In the body it is partly converted into phenobarbital, another anticonvulsant; its effect on essential tremor was reported in 1981, starting from the observation of a single patient.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- PrimidoneBP 293
- Primidone CRSEP P2950000
More products in the Primidone family
Pharmacopoeial impurityPrimidone EP Impurity A (as Hydrate)Cat. No. P-P190-002CAS 80866-90-6
Pharmacopoeial impurityPrimidone EP Impurity CCat. No. P-P190-003CAS 90-26-6
Pharmacopoeial impurityPrimidone EP Impurity DCat. No. P-P190-004CAS 80544-75-8
Pharmacopoeial impurityPrimidone EP Impurity ECat. No. P-P190-005CAS 90-27-7
Pharmacopoeial impurityPrimidone EP Impurity FCat. No. P-P190-006CAS 1189504-46-8
Pharmacopoeial impurityPrimidone USP Related Compound ACat. No. P-P190-007CAS 7206-76-0
Isotopically labelledPrimidone-d5Cat. No. P-P190-008CAS 73738-06-4Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.