Active ingredientProbenecidCat. No. P-P193-001CAS 57-66-9
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Pharmacopoeial impurity · Probenecid family
Pharmaceutical analytical standardProbenecid EP Impurity A
Synonyms: 4-Sulfobenzoic acid, p-Sulfobenzoic acid, Benzoic acid, 4-sulfo-, Para-Sulfobenzoic acid, Para-Sulphobenzoic acid, p-carboxybenzenesulfonic acid
- Cat. No.
- P-P193-002
- CAS
- 636-78-2
- Alternative CAS
- 22959-32-6 (potassium salt)
- 5399-63-3 (potassium salt)
- Formula
- C7H6O5S
- Molecular weight
- 202.18 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Probenecid
A uricosuric drug that helps the kidneys excrete excess uric acid, approved in the United States in 1951 and still used today for gout and hyperuricaemia; it was developed as an alternative to caronamide.
Did you know?It competes with penicillin for the same kidney transporter and slows its elimination: this is why it has been given together with the antibiotic to keep its blood levels higher.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Probenecid family
Active ingredientProbenecidCat. No. P-P193-001CAS 57-66-9
Pharmacopoeial impurityProbenecid EP Impurity BCat. No. P-P193-003CAS 723-42-2
Pharmacopoeial impurityProbenecid EP Impurity DCat. No. P-P193-004CAS 70190-76-0
MetaboliteProbenecid Acyl beta-D-GlucuronideCat. No. P-P193-005CAS 34017-15-7
Isotopically labelledProbenecid-d14Cat. No. P-P193-007CAS 1189657-87-1
Impurity4-(Dimethylsulfamoyl)benzoic acidCat. No. P-P193-008CAS 1206-37-7
ImpurityHydroxy ProbenecidCat. No. P-P193-009CAS 28242-02-6
ImpurityProbenecid Impurity 1Cat. No. P-P193-010Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.