Pharmacopoeial impurityProguanil EP Impurity C HydrochlorideCat. No. P-P202-003CAS 13590-98-2
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Active ingredient · Proguanil family
Pharmaceutical analytical standardProguanil Hydrochloride
Synonyms: Chloroguanide hydrochloride, Chlorguanide hydrochloride, Paludrine, Diguanyl, Chloroquanil, Bigumalum, Drinupal, Guanatol, Palusil, Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-, monohydrochloride, Chloriguane, Hydrochloride, Chloroguanide, Tirian hydrochloride, Palusil hydrochloride, Drinupal hydrochloride, Guanatol hydrochloride, Chloroguanidine hydrochloride, BIGUANIDE, 1-(p-CHLOROPHENYL)-5-ISOPROPYL-, MONOHYDROCHLORIDE, N-(4-Chlorophenyl)-N'-(propan-2-yl)triimidodicarbonic diamide--hydrogen chloride (1/1)
- Cat. No.
- P-P202-001
- CAS
- 637-32-1
- Alternative CAS
- 500-92-5 (free base)
- 7586-61-0 (sulfate)
- Formula
- C11H16ClN5·HCl
- Molecular weight
- 290.19 g/mol
- Category
- Active ingredient (API)
An antimalarial of the biguanide class, introduced in 1945 after research by the British chemists Frank Rose and Frank Curd: it is also used together with atovaquone to prevent and treat malaria.
Did you know?It is a prodrug: the liver converts it into cycloguanil, which blocks the parasite's dihydrofolate reductase enzyme. When combined with atovaquone, however, it seems to act through a different mechanism.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Proguanil HydrochlorideBP 297
- Proguanil for system suitability CRSEP Y0001885
- Proguanil hydrochloride CRSEP Y0001901
More products in the Proguanil family
Pharmacopoeial impurityProguanil EP Impurity C HydrochlorideCat. No. P-P202-003CAS 13590-98-2
Pharmacopoeial impurityProguanil EP Impurity D HydrochlorideCat. No. P-P202-004CAS 35708-82-8
Pharmacopoeial impurityProguanil EP Impurity ECat. No. P-P202-005CAS 1482-62-8
ImpurityProguanil Impurity 1 HydrochlorideCat. No. P-P202-007
Impurity1-Cyano-3-(1-methylethyl)guanidineCat. No. P-P202-008CAS 44830-55-9
Active ingredientProguanilCat. No. P-P202-009CAS 500-92-5Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.