Isotopically labelledcis-4-Hydroxy-L-Proline-13C5Cat. No. P-P204-002
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Active ingredient · Proline family
Pharmaceutical analytical standardProline
Synonyms: L-Proline, L-Prolin, L-alpha-Pyrrolidinecarboxylic acid, FEMA No. 3319, PRO (IUPAC abbreviation), L-Pro, NSC 46703, Prolinum (Latin), H-Pro-OH, L-Pyrrolidine-2-carboxylic acid, FEMA Number 3319, Carboxypyrrolidine, H-Pro, Pro-OH, L-Pro-OH, Pharmakon1600-01301007, NSC 760114
- Cat. No.
- P-P204-001
- CAS
- 147-85-3
- Alternative CAS
- 7776-34-3 (hydrochloride)
- 15383-56-9 (sodium salt)
- 25191-13-3 (alternative CAS, same compound)
- 4305-67-3 (alternative CAS, same compound)
- 37159-97-0 (alternative CAS, same compound)
- Formula
- C5H9NO2
- Molecular weight
- 115.13 g/mol
- Category
- Active ingredient (API)
A non-essential proteinogenic amino acid, the only one with a secondary amine: its side chain loops back onto the nitrogen to form a ring, making proteins more rigid. With hydroxyproline it is a main building block of collagen.
Did you know?It was isolated in 1900 by Richard Willstätter and the following year by Emil Fischer from milk casein; its name comes from pyrrolidine, the ring that defines it.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Proline CRSEP P3350000
More products in the Proline family
Isotopically labelledcis-4-Hydroxy-L-Proline-13C5Cat. No. P-P204-002
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Isotopically labelledL-Proline-2,5,5-d3Cat. No. P-P204-005CAS 65807-22-9
Isotopically labelledtrans-4-Hydroxy-L-proline-2,5,5-d3Cat. No. P-P204-007CAS 1356016-86-8
Nitrosamine1-Nitroso-L-proline Methyl EsterCat. No. P-P204-008CAS 35909-01-4
NitrosamineN-Nitroso L-ProlinamideCat. No. P-P204-009CAS 79108-51-3
NitrosamineN-Nitroso rac-ProlineCat. No. P-P204-010CAS 2571-28-0
NitrosamineN-Nitroso-D-ProlineCat. No. P-P204-011CAS 42022-03-7Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.