Active ingredientProtirelinCat. No. P-P226-001CAS 24305-27-9
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Pharmacopoeial impurity · Protirelin family
Pharmaceutical analytical standardProtirelin EP Impurity C
Synonyms: 5-Oxo-L-prolyl-L-histidine, pGlu-His-OH, L-pyroglutamyl-L-histidine, LHRH (1-2) (free acid), Pyr-His
- Cat. No.
- P-P226-004
- CAS
- 32159-22-1
- Alternative CAS
- N/A
- Formula
- C11H14N4O4
- Molecular weight
- 266.26 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Protirelin
It is the pharmaceutical form of TRH, the hypothalamic hormone that triggers the release of thyrotropin: a small three-amino-acid peptide whose structure was determined in 1969, used in the diagnostic TRH test.
Did you know?To find it, the rival teams of Roger Guillemin and Andrew Schally processed a huge number of sheep and pig brains; both claimed priority and in 1977 they shared the Nobel Prize in Medicine.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Protirelin family
Active ingredientProtirelinCat. No. P-P226-001CAS 24305-27-9
Pharmacopoeial impurityProtirelin EP Impurity BCat. No. P-P226-003CAS 50894-61-6
Pharmacopoeial impurityProtirelin EP Impurity DCat. No. P-P226-005CAS 24769-58-2
Pharmacopoeial impurityProtirelin EP Impurity ECat. No. P-P226-006CAS 53109-32-3Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.