Pharmacopoeial impurityPyrazinamide EP Impurity BCat. No. P-P237-002CAS 19847-12-2
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Active ingredient · Pyrazinamide family
Pharmaceutical analytical standardPyrazinamide
Synonyms: pyrazine-2-carboxamide, Pyrazinecarboxamide, Aldinamide, Zinamide, Pirazimida, Pirazinamid, Unipyranamide, Aldinamid, Farmizina, Pyrazinoic acid amide, Eprazin, Novamid, Tebrazid, Pyrafat, Pyrazine carboxylamide, Pyrazineamide, Isopas, Pyrazinecarboxylic acid amide, Pirazinamida, Pyrazide, Rozide, Pirazinamide, Pyramizade, NSC 14911, Pirilene, Tisamid, Piraldina, Pyrazinamdie, Rifafour, Rifafour e-200, Pyrizinamide, Pyrazine-2-carboxylic acid amide, Pirazinecarboxamide, Pyrazine, 2-carbamoyl-, Pharmakon1600-01500518, NSC 757304
- Cat. No.
- P-P237-001
- CAS
- 98-96-4
- Alternative CAS
- N/A
- Formula
- C5H5N3O
- Molecular weight
- 123.11 g/mol
- Category
- Active ingredient (API)
An antituberculosis drug always used with other medicines, such as isoniazid and rifampicin: synthesised in 1936, it was not used against tuberculosis until 1952. It is a prodrug that the bacterium converts into pyrazinoic acid.
Did you know?It was tested because it resembles nicotinamide, already known to act against tuberculosis; curiously, in the test tube at neutral pH it has no effect at all on the bacillus.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- PyrazinamideBP 906
- Pyrazinamide CRSEP P4050000
More products in the Pyrazinamide family
Pharmacopoeial impurityPyrazinamide EP Impurity BCat. No. P-P237-002CAS 19847-12-2
Isotopically labelledPyrazinamide-d3Cat. No. P-P237-003CAS 1432059-16-9
Isotopically labelledPyrazinamide-d3-15NCat. No. P-P237-004CAS 1246817-81-1
Impurity5-Hydroxy-PyrazinamideCat. No. P-P237-005CAS 13924-96-4
ImpurityPyrazinoic AcidCat. No. P-P237-006CAS 98-97-5Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.