Active ingredientPyrimethamineCat. No. P-P240-001CAS 58-14-0
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Pharmacopoeial impurity · Pyrimethamine family
Pharmaceutical analytical standardPyrimethamine EP Impurity A
Synonyms: Pyrimethamine Impurity 2, 2-(4-Chlorophenyl)-3-oxopentanenitrile, Valeronitrile, 2-(p-chlorophenyl)-3-oxo-, Benzeneacetonitrile, 4-chloro-alpha-(1-oxopropyl)-, Pyrimethamine impurity a (ep impurity), a-(4-Chlorophenyl)-a-propionylacetonitrile, alpha-(4-Chlorophenyl)-alpha-propionylacetonitrile, alpha-propionyl-p-chlorophenyl acetonitrile
- Cat. No.
- P-P240-002
- CAS
- 55474-40-3
- Alternative CAS
- N/A
- Formula
- C11H10ClNO
- Molecular weight
- 207.66 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Pyrimethamine
An antiparasitic that blocks the enzyme dihydrofolate reductase, discovered in 1952 and in use since 1953: born to fight malaria, it is also used against toxoplasmosis, together with sulfadiazine, and it has been included in the WHO List of Essential Medicines.
Did you know?It was developed by Gertrude Elion, an American biochemist and pharmacologist who in 1988 received the Nobel Prize in Physiology or Medicine for discovering important principles of drug treatment.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Pyrimethamine family
Active ingredientPyrimethamineCat. No. P-P240-001CAS 58-14-0
Pharmacopoeial impurityPyrimethamine EP Impurity DCat. No. P-P240-003CAS 55474-41-4
Isotopically labelledPyrimethamine-d3Cat. No. P-P240-004CAS 1189936-99-9
Isotopically labelledPyrimethamine-d5Cat. No. P-P240-005
ImpurityPyrimethamine impurity b (ep impurity)Cat. No. P-P240-006CAS 3275-44-3
ImpurityPyrimethamine Impurity 1Cat. No. P-P240-007
ImpurityPyrimethamine N1-OxideCat. No. P-P240-008
ImpurityPyrimethamine N3-OxideCat. No. P-P240-009CAS 91284-15-0Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.