Pharmacopoeial impurityPyrimethamine EP Impurity ACat. No. P-P240-002CAS 55474-40-3
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Active ingredient · Pyrimethamine family
Pharmaceutical analytical standardPyrimethamine
Synonyms: 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine, Daraprim, Chloridine, Chloridin, Diaminopyritamin, Ethylpyrimidine, Pirimecidan, Pirimetamin, Chloridyn, Pirimetamina, Darachlor, Erbaprelina, Khloridin, Tindurin, Malocid, Primethamine, Pyremethamine, Pyrimidine, 2,4-diamino-5-(p-chlorophenyl)-6-ethyl-, Malocide, Malacid, Darapram, Daraprime, Maloprim, Daraclor, Tinduring, Pyrimidine,4-diamino-5-(p-chlorophenyl)-6-ethyl-
- Cat. No.
- P-P240-001
- CAS
- 58-14-0
- Alternative CAS
- 53640-38-3 (sulfate)
- 19085-09-7 (hydrochloride)
- 874817-46-6 (nitrate)
- 7681-25-6 (phosphate)
- Formula
- C12H13ClN4
- Molecular weight
- 248.71 g/mol
- Category
- Active ingredient (API)
An antiparasitic that blocks the enzyme dihydrofolate reductase, discovered in 1952 and in use since 1953: born to fight malaria, it is also used against toxoplasmosis, together with sulfadiazine, and it has been included in the WHO List of Essential Medicines.
Did you know?It was developed by Gertrude Elion, an American biochemist and pharmacologist who in 1988 received the Nobel Prize in Physiology or Medicine for discovering important principles of drug treatment.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- PyrimethamineBP 1227
- Pyrimethamine CRSEP P4200000
More products in the Pyrimethamine family
Pharmacopoeial impurityPyrimethamine EP Impurity ACat. No. P-P240-002CAS 55474-40-3
Pharmacopoeial impurityPyrimethamine EP Impurity DCat. No. P-P240-003CAS 55474-41-4
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ImpurityPyrimethamine Impurity 1Cat. No. P-P240-007
ImpurityPyrimethamine N1-OxideCat. No. P-P240-008
ImpurityPyrimethamine N3-OxideCat. No. P-P240-009CAS 91284-15-0Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.