Active ingredientRibociclibCat. No. P-R049-001CAS 1211441-98-3
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Impurity or related compound · Ribociclib family
Pharmaceutical analytical standardRibociclib Impurity 12
Synonyms: 3-[2-[(2-Chloro-7-cyclopentylpyrrolo[2,3-d]pyrimidin-6-yl)methoxy]-4-(cyclopentylamino)pyrimidin-5-yl]prop-2-yn-1-ol
- Cat. No.
- P-R049-029
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C24H27ClN6O2
- Molecular weight
- 466.97 g/mol
- Category
- Impurity or related compound
Family: Ribociclib
An inhibitor of the kinases CDK4 and CDK6, which drive the division of tumour cells: approved in the United States in 2017, together with hormone therapy, for advanced hormone receptor-positive, HER2-negative breast cancer.
Did you know?Its targets work together with cyclins, proteins discovered in 1982 by Tim Hunt while studying fertilised sea urchin eggs: a discovery rewarded with the Nobel Prize in 2001.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Ribociclib family
Active ingredientRibociclibCat. No. P-R049-001CAS 1211441-98-3
Active ingredientRibociclib SuccinateCat. No. P-R049-002CAS 1374639-75-4
Isotopically labelledRibociclib D6 HydrochlorideCat. No. P-R049-003CAS 2934109-69-8
Isotopically labelledRibociclib-d6Cat. No. P-R049-004CAS 1328934-40-2
Isotopically labelledRibociclib-d8Cat. No. P-R049-005CAS 2167898-24-8
NitrosamineN1-Nitroso RibociclibCat. No. P-R049-006
NitrosamineN-Nitroso N1-Nitroso Ribociclib Impurity 1Cat. No. P-R049-007
NitrosamineN2-Nitroso RibociclibCat. No. P-R049-008Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.